Journal article
Transcutaneous spinal cord stimulation at alternating intensities preferentially prevents the development of spasticity after contusion SCI in rat
The Journal of physiology, v 603(17), pp 4845-4865
10 Aug 2025
PMID: 40785043
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract figure legend Previous work in humans and rodents has identified transcutaneous spinal cord stimulation as a promising strategy to reduce spasticity and hyperreflexia after spinal cord injury. The objective of this study was to deliver stimulation protocols with the intensity set (1) above motor threshold, (2) below motor threshold or (3) alternating between supra‐and subthreshold; and evaluate whether it differentially influences diverse outcome measures associated with spasticity, including low frequency‐dependent depression of the H‐reflex, motor responses in response to ankle stretch and toe pinch, and the expression of KCC2 protein in lumbar motoneurons.
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Details
- Title
- Transcutaneous spinal cord stimulation at alternating intensities preferentially prevents the development of spasticity after contusion SCI in rat
- Creators
- Dillon C. Malloy - Drexel University, Neurobiology and AnatomyJadwiga N. Bilchak - Drexel UniversityMarie‐Pascale Côté - Drexel University, Neurobiology and Anatomy
- Publication Details
- The Journal of physiology, v 603(17), pp 4845-4865
- Publisher
- John Wiley and Sons Inc
- Number of pages
- 21
- Grant note
- NS119475 / ; 647897 / ; PA / ;
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001546403300001
- Scopus ID
- 2-s2.0-105012831507
- Other Identifier
- 991022080221704721
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InCites Highlights
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- Web of Science research areas
- Neurosciences
- Physiology