Journal article
Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice
Neuroreport, v 18(7), pp 713-717
07 May 2007
PMID: 17426605
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this work, we studied transgenic glial fibrillary acidic protein-IkappaBalpha-dn mice that selectively inactivate the classical nuclear factor kappaB pathway by overexpressing the inhibitory protein of kappaBalpha in astrocytes, under the control of glial fibrillary acidic protein promoter. We sought to determine if glial nuclear factor kappaB inhibition decreases formalin pain. Formalin testing was carried out on 25-35 g littermate adult male wild-type and transgenic C57Bl/6 mice. Formalin increased spinal cord c-Fos expression and glial fibrillary acidic protein immunostaining in both wild-type and transgenic mice. Transgenic glial fibrillary acidic protein-inhibitory protein of kappaBalpha-dn mice had lower duration of formalin-induced paw-licking behavior. These data support a role of glial nuclear factor kappaB inhibition in reducing pain after peripheral nerve inflammation.
Metrics
Details
- Title
- Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice
- Creators
- Eugene S Fu - University of MiamiYan Ping Zhang - University of Miami*Jacqueline Sagen - Neurological SurgeryZong Qi YangJohn R Bethea - Neurological Surgery
- Publication Details
- Neuroreport, v 18(7), pp 713-717
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000245856000019
- Scopus ID
- 2-s2.0-34247242055
- Other Identifier
- 991020099017804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences