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Journal article
Transient Inhibition of Mediodorsal Thalamus during Early Adolescence Induces Hypofrontality and Social memory Deficits in Young Adulthood
Biological psychiatry global open science, v 5(4), 100486
Jul 2025
PMID: 40330221
Abstract
AbstractBackgroundThe dysconnectivity between the mediodorsal thalamus (MD) and medial prefrontal cortex (mPFC) during adolescence is linked to developmental, psychiatric disorders and social, behavioral deficits. However, the precise mechanisms underlying these impairments remain elusive. MethodsWe transiently inhibited MD activity in adolescent mice. ResultsWe revealed that this transient MD inhibition during adolescence led to impaired social memory in adulthood. The neuronal excitability of both MD and mPFC excitatory neurons decreased. Meanwhile, excitatory synaptic transmission in excitatory neurons in the mPFC was impaired. In vivo calcium imaging showed a persistent reduction of general calcium activity in mPFC. Unexpectedly, there were opposing alterations in intrinsic excitability and synaptic function changes in somatostatin (SST) but not in parvalbumin (PV) interneurons. ConclusionsOur findings provide insights into the role of MD input activity in shaping the circuit and functional maturation of mPFC that is critical for the normal development of social memory and abnormal deficits in psychiatric disorders.
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- Title
- Transient Inhibition of Mediodorsal Thalamus during Early Adolescence Induces Hypofrontality and Social memory Deficits in Young Adulthood
- Creators
- Sha-Sha Yang - Jinshan Hospital of Fudan UniversityQuansheng He - Jinshan Hospital of Fudan UniversityXinyang Gu - Fudan UniversityShouPei Liu - Jinshan Hospital of Fudan UniversityWei Ke - Jinshan Hospital of Fudan UniversityLiang Chen - Fudan UniversityBo Li - Jinshan Hospital of Fudan UniversityYousheng Shu - Jinshan Hospital of Fudan UniversityWen-Jun Gao - Drexel University
- Publication Details
- Biological psychiatry global open science, v 5(4), 100486
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- National Institutes of Health: NIHR21MH110678, NIHR01MH085666 National Natural Science Foundation of China: T2222006, 32130044, T2241002 Shanghai Municipal Science and Technology Major Project, Shanghai Pilot Program for Basic Research from Fudan University at China: 21TQ1400100/22TQ019 Brain Science Interdisciplinary Integration Exploration Project from Fudan University Ministry of Education (MOE) Frontiers Center of China
This work was supported by the National Institutes of Health (Grant Nos. NIHR21MH110678 and NIHR01MH085666 [to W-JG] ) ; National Natural Science Foundation of China (Grant Nos. T2241002 and 32130044 [to YS] ) ; National Natural Science Foundation of China (Grant No. T2222006 [to BL] ) ; Shanghai Municipal Science and Technology Major Project, Shanghai Pilot Program for Basic Research from Fudan University at China (Grant No. 21TQ1400100/22TQ019 [to BL] ) ; and an award from the Brain Science Interdisciplinary Integration Exploration Project from Fudan University Ministry of Education (MOE) Frontiers Center of China (to BL) . S-SY and W-JG were responsible for conceptualization.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001479009800001
- Scopus ID
- 2-s2.0-105003291315
- Other Identifier
- 991022041489904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Psychiatry