Journal article
Transient Myeloproliferative Disorder in Neonates With and Without Down Syndrome A Tale of 2 Syndromes
Journal of pediatric hematology/oncology, v 30(11), pp 860-864
01 Nov 2008
PMID: 18989165
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transient myeloproliferative disorder (TMD) in newborns with Down syndrome (DS) has been well described. We report 4 newborns, 2 with DS and 2 without DS, who developed TMD. One newborn with DS developed multiorgan failure and died despite treatment with low-dose cytarabine In 3 newborns, the TMD resolved spontaneously. Two of these patients, 1 with and 1 without DS developed leukemia on subsequent follow-up and were treated succesfully. We reviewed the clinical and laboratory data on 14 non-DS infants with TMD reported in the literature. According to limited data, these patients Lire more likely to develop leukemia than DS patients, however their outcome is better.
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Details
- Title
- Transient Myeloproliferative Disorder in Neonates With and Without Down Syndrome A Tale of 2 Syndromes
- Creators
- Nataly Apollonsky - Schneider Children's HospitalAshok Shende - Schneider Children's HospitalIhsane Ouansafi - Schneider Children's HospitalJudith Brody - Schneider Children's HospitalMark Atlas - Schneider Children's HospitalBanu Aygun - Schneider Children's Hospital
- Publication Details
- Journal of pediatric hematology/oncology, v 30(11), pp 860-864
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000260727000013
- Scopus ID
- 2-s2.0-58149147635
- Other Identifier
- 991021448165304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Hematology
- Oncology
- Pediatrics