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Journal article
Transient decreases in forelimb gait and ground reaction forces following rotator cuff injury and repair in a rat model
Journal of biomechanics, v 43(4), pp 778-782
03 Mar 2010
PMID: 19931082
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Due to inadequate healing, surgical repairs of torn rotator cuff tendons often fail, limiting the recovery of upper extremity function. The rat is frequently used to study rotator cuff healing; however, there are few systems capable of quantifying forelimb function necessary to interpret the clinical significance of tissue level healing. We constructed a device to capture images, ground reaction forces and torques, as animals ambulated in a confined walkway, and used it to evaluate forelimb function in uninjured control and surgically injured/repaired animals. Ambulatory data were recorded before (D-1), and 3, 7, 14, 28 and 56 days after surgery. Speed as well as step width and length were determined by analyzing ventral images, and ground reaction forces were normalized to body weight. Speed averaged 22 +/- 6 cm/s and was not affected by repair or time. Step width and length of uninjured animals compared well to values measured with our previous system. Forelimbs were used primarily for braking (-1.6 +/- 1.5% vs +2.5 +/- 0.6%), bore less weight than hind limbs (49 +/- 5% vs 58 +/- 4%), and showed no differences between sides (49 +/- 5% vs 46 +/- 5%) for uninjured control animals. Step length and ground reaction forces of the repaired animals were significantly less than control initially (days 3,7 and 14 post-surgery), but not by day 28. Our new device provided uninjured ambulatory data consistent with our previous system and available literature, and measured reductions in forelimb function consistent with the deficit expected by our surgical model. (C) 2009 Elsevier Ltd. All rights reserved.
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Details
- Title
- Transient decreases in forelimb gait and ground reaction forces following rotator cuff injury and repair in a rat model
- Creators
- Joseph J. Sarver - University of PennsylvaniaMichael I. Dishowitz - University of PennsylvaniaSoung-Yon Kim - Kangwon National UniversityLouis J. Soslowsky - University of Pennsylvania
- Publication Details
- Journal of biomechanics, v 43(4), pp 778-782
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- AR051000 / NIH/NIAMS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) R01AR051000 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) AR050950 / NIH/NIAMS supported Penn Center for Musculoskeletal Disorders; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000276008500027
- Scopus ID
- 2-s2.0-77952537233
- Other Identifier
- 991019323783004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical