Journal article
Transition to young adulthood in Ullrich-Turner syndrome: Neurodevelopmental changes
American journal of medical genetics, v 79(2), pp 140-147
01 Sep 1998
PMID: 9741472
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Abstract
Studies describing the neurocognitive profile of Ullrich-Turner syndrome (UTS) have focused primarily on neurodevelopmental changes in childhood and adolescence or in adults with UTS. The objective of the present study was to describe neurodevelopmental changes that occur in UTS females during the transition from adolescence to young-adulthood. The subjects included 99 females with UTS and 89 normal female controls matched for age and socioeconomic status. Subjects were between the ages of 13 and 21 years. All subjects received a battery of neurocognitive tests designed to assess general cognitive ability, academic achievement, memory, language, executive function, visual-spatial/perceptual and motor skills, affect recognition, attention, and motor skills. Results from our study indicated that females with UTS performed significantly less well than controls on measures of spatial/perceptual skills, visual-motor integration, affect recognition, visual memory, attentional abilities, and executive function, consistent with previous reports of cognitive abilities in adolescent UTS females. Moreover, our results indicate that decreased performance in some of these areas persists through late adolescence and into early adulthood while improvement occurs in other areas. It is possible that catch-up in certain cognitive deficiencies in UTS females represents a maturational/developmental lag, Alternatively, the neurodevelopmental changes that were observed in UTS females may result from the cumulative effects of estrogen replacement therapy during adolescence. Therapeutic interventions specific to the demands of young-adulthood are also discussed. Am. J. Med. Genet. 79:140-147, 1998, (C) 1998 Wiley-Liss, Inc.
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Details
- Title
- Transition to young adulthood in Ullrich-Turner syndrome: Neurodevelopmental changes
- Creators
- S M RomansG StefanatosD P RoeltgenH KushnerJ L Ross
- Publication Details
- American journal of medical genetics, v 79(2), pp 140-147
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- R01NS029857 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) NS29857 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000075745400010
- Scopus ID
- 2-s2.0-0032167960
- Other Identifier
- 991019168024904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity