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Journal article
Transitioning from parenteral treprostinil to inhaled treprostinil in patients with pulmonary arterial hypertension
Pulmonary circulation, v 3(1), pp 116-120
01 Jan 2013
PMID: 23662183
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Treprostinil is a potent prostacyclin vasodilator indicated for the treatment of pulmonary arterial hypertension (PAH, World Health Organization Group I). Previously, treprostinil was available only in subcutaneous (SC) or intravenous (IV) formulations. Availability of an inhaled formulation of treprostinil has provided clinicians with an alternative to continuous SC or IV treprostinil in appropriate patients. Stable PAH patients whose quality of life has been dramatically impacted by side effects of parenteral therapy or those who have had recurrent, life-threatening bloodstream infections but are otherwise responding well to treatment may be the candidates for continuing prostacyclin therapy with inhaled treprostinil. However, there is little clinical experience with transitioning patients from parenteral to inhaled treprostinil. We present the results of two cases that highlight important considerations in transitioning patients from parenteral to inhaled therapy, including the pharmacologic and clinical equivalence of formulations, dose titration of formulations and suggested criteria for patient selection.
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Details
- Title
- Transitioning from parenteral treprostinil to inhaled treprostinil in patients with pulmonary arterial hypertension
- Creators
- Amresh Raina - Allegheny General HospitalJames C. Coons - Allegheny General HospitalManreet Kanwar - Allegheny General HospitalSrinivas Murali - Allegheny General HospitalGeorge Sokos - Allegheny General HospitalRaymond L. Benza - Allegheny General Hospital
- Publication Details
- Pulmonary circulation, v 3(1), pp 116-120
- Publisher
- Medknow Publications
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); Cardiology
- Web of Science ID
- WOS:000209981400015
- Scopus ID
- 2-s2.0-84899628597
- Other Identifier
- 991021932103504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System