Journal article
Translation and Validation of 10/66 Dementia Diagnostic Battery in Urdu in Karachi, Pakistan
Alzheimer disease and associated disorders, v 34(2), pp 163-169
01 Apr 2020
PMID: 31651419
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: The 10/66 dementia research group (DRG) diagnostic tool was devised to diagnose dementia in people with low education in low and middle-income countries. This study aimed to validate the 10/66 DRG tool in Urdu in Pakistan. Methodology: People older than or equal to 60 years were included: (1) With normal cognition: no/low education, high education, and depression; (2) People with mild and moderate dementia. The diagnostic and statistical manual IV-TR clinician diagnosis was used as the gold standard for dementia. The Clinician Dementia Rating scale was used to rate dementia severity. The geriatric mental status AGECAT stage I output was used to diagnose depression. The 10/66 battery was comprised of CSI-D (cognitive screening instrument for dementia), CERAD (consortium to establish a registry of Alzheimer disease), and animal naming test. Result: The sensitivity and specificity of CSI-D COG score for diagnosing dementia was 86.7% and 72.1%, for CSI-D DF score was 71.1% and 96.1%, for CERAD-10 word list delayed recall was 85.9% and 62.2% at a cut point of >= 5 words, and 70.3% and 97.7% for 10/66 diagnostic algorithm. Conclusions: The 10/66 DRG tool is a valid instrument for diagnosing dementia in the Urdu-speaking population, including with low education and depression, in Pakistan.
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Details
- Title
- Translation and Validation of 10/66 Dementia Diagnostic Battery in Urdu in Karachi, Pakistan
- Creators
- Qurat ul Ain Khan - Neurocare Clin, AlKhaleej Tower,Off 804,Shaheed E Millat Rd, Karachi 74800, PakistanMartin J. Prince - King's College LondonWardah Khalid - University of EdinburghMaryam Zulfiqar - UPMC Health System
- Publication Details
- Alzheimer disease and associated disorders, v 34(2), pp 163-169
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- 144003PSY / AKU-University Research Council (URC Grant)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000536936800010
- Scopus ID
- 2-s2.0-85074430955
- Other Identifier
- 991022042557904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Pathology