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Journal article
Translation of Collagen Ultrastructure to Biomaterial Fabrication for Material-Independent but Highly Efficient Topographic Immunomodulation
Advanced materials (Weinheim), v 33(33), pp e2101228-n/a
Aug 2021
PMID: 34240485
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Supplement-free induction of cellular differentiation and polarization solely through the topography of materials is an auspicious strategy but has so far significantly lagged behind the efficiency and intensity of media-supplementation-based protocols. Consistent with the idea that 3D structural motifs in the extracellular matrix possess immunomodulatory capacity as part of the natural healing process, it is found in this study that human-monocyte-derived macrophages show a strong M2a-like prohealing polarization when cultured on type I rat-tail collagen fibers but not on collagen I films. Therefore, it is hypothesized that highly aligned nanofibrils also of synthetic polymers, if packed into larger bundles in 3D topographical biomimetic similarity to native collagen I, would induce a localized macrophage polarization. For the automated fabrication of such bundles in a 3D printing manner, the strategy of "melt electrofibrillation" is pioneered by the integration of flow-directed polymer phase separation into melt electrowriting and subsequent selective dissolution of the matrix polymer postprocessing. This process yields nanofiber bundles with a remarkable structural similarity to native collagen I fibers, particularly for medical-grade poly(ε-caprolactone). These biomimetic fibrillar structures indeed induce a pronounced elongation of human-monocyte-derived macrophages and unprecedentedly trigger their M2-like polarization similar in efficacy as interleukin-4 treatment.
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Details
- Title
- Translation of Collagen Ultrastructure to Biomaterial Fabrication for Material-Independent but Highly Efficient Topographic Immunomodulation
- Creators
- Matthias Ryma - Bavarian Polymer InstituteTina Tylek - Bavarian Polymer InstituteJulia Liebscher - Bavarian Polymer InstituteCarina Blum - Bavarian Polymer InstituteRobin Fernandez - Bavarian Polymer InstituteChristoph Böhm - Department of Functional Materials in Medicine and Dentistry at the Institute of Functional Materials and Biofabrication and Bavarian Polymer Institute, Julius-Maximilians-Universität Würzburg, 97070, Würzburg, GermanyWolfgang Kastenmüller - University of WürzburgGeorg Gasteiger - University of WürzburgJürgen Groll - Bavarian Polymer Institute
- Publication Details
- Advanced materials (Weinheim), v 33(33), pp e2101228-n/a
- Publisher
- Wiley
- Grant note
- 617989 / European Research Council 326998133 / DFG
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000670801200001
- Scopus ID
- 2-s2.0-85109374934
- Other Identifier
- 991019292131304721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter