Journal article
Transmission modes of the mammalian gut microbiota
Science (American Association for the Advancement of Science), v 362(6413), pp 453-457
26 Oct 2018
PMID: 30361372
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mammals house a diversity of bacteria that affect health in various ways, but the routes by which bacterial lineages are transmitted between hosts remain poorly understood. We experimentally determined microbiota transmission modes by deriving 17 inbred mouse lines from two wild populations and monitoring their gut microbiotas for up to 11 host generations. Individual- and population-level microbiota compositions were maintained within mouse lines throughout the experiment, indicating predominantly vertical inheritance of the microbiota. However, certain bacterial taxa tended to be exchanged horizontally between mouse lines. Consistent with evolutionary theory, the degree of horizontal transmission predicted bacterial genera with pathogenic representatives responsible for human infections and hospitalizations.
Metrics
Details
- Title
- Transmission modes of the mammalian gut microbiota
- Creators
- Andrew H Moeller - Museum of Vertebrate ZoologyTaichi A Suzuki - University of California, BerkeleyMegan Phifer-Rixey - University of California, BerkeleyMichael W Nachman - Museum of Vertebrate Zoology
- Publication Details
- Science (American Association for the Advancement of Science), v 362(6413), pp 453-457
- Publisher
- American Association for the Advancement of Science (AAAS)
- Grant note
- R01 GM074245 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000450441900049
- Scopus ID
- 2-s2.0-85055613395
- Other Identifier
- 991021230006004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Multidisciplinary Sciences