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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Transneuronal tracing to map connectivity in injured and transplanted spinal networks
Experimental neurology, v 351, 113990
May 2022
PMID: 35085573
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It has become widely appreciated that the spinal cord has significant neuroplastic potential, is not hard-wired, and that with traumatic injury and anatomical plasticity, the networks that we once understood now comprise a new anatomy. Harnessing advances in neuroanatomical tracing to map the neuronal networks of the intact and injured spinal cord has been crucial to elucidating this new spinal cord anatomy. Many new techniques have been developed to identify these networks using a variety of retrograde and anterograde tracers. One method of tracing that has become more widely used to map anatomical changes is transneuronal tracing. Viral tracers are being increasingly used to map spinal networks, leading to an advanced understanding of spinal circuitry and host-donor-host interactions between the injured spinal cord and neural transplants. This review will highlight advances in neuronal tracing, specifically using pseudorabies virus (PRV), and its use in the intact, injured, and transplanted spinal cord.
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Details
- Title
- Transneuronal tracing to map connectivity in injured and transplanted spinal networks
- Creators
- Tara A. Fortino - Drexel UniversityMargo L. Randelman - Drexel UniversityAdam A. Hall - Drexel UniversityJasbir Singh - University of FloridaDavid C. Bloom - University of FloridaEsteban Engel - Princeton UniversityDaniel J. Hoh - University of FloridaShaoping Hou - Drexel UniversityLyandysha V. Zholudeva - Gladstone InstitutesMichael A. Lane - Drexel University
- Publication Details
- Experimental neurology, v 351, 113990
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000776069500001
- Scopus ID
- 2-s2.0-85123725465
- Other Identifier
- 991019167751304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences