Journal article
Transorbital Alternating Current Stimulation in a Double-Masked Randomized Clinical Trial: Visual Functional Effect and Quality of Life
Ophthalmology science (Online), v 5(1), 100614
2025
PMID: 39584183
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine the efficacy and safety of repetitive transorbital alternating current stimulation (rtACS) treatment by assessing vision-related quality of life and visual function outcome in subjects treated with rtACS versus sham-control.
Double masked, randomized, sham-controlled clinical trial (NCT03188042).
Sixteen subjects with moderate-to-advanced glaucoma (visual field [VF] mean deviation [MD] ≤−6.00 decibels) randomized into sham (9 subjects) or rtACS intervention (7 subjects) groups.
Subjects underwent 10 rtACS sessions over 2 weeks. All subjects had comprehensive ocular examination at baseline, 1-week, and 4-weeks posttreatment.
Visual acuity (VA), contrast sensitivity (CS), VF MD, number of threshold sensitivity points that changed or were unchanged, and vision-related quality of life (VR-QoL) questionnaire scores.
The rtACS group showed a significantly greater improvement from baseline to 4 weeks posttreatment compared with sham in VR-QoL domains including near activities (P < 0.01), dependency (P = 0.03), social functioning (P = 0.03), mental health (P < 0.01) and in the overall composite score (P = 0.04). No significant changes were detected with VA, CS, and VF analyses for either group. No serious adverse events were noted in either study group.
Repetitive transorbital alternating current stimulation therapy showed a significant beneficial effect on several domains of VR-QoL. Further studies will determine its utility in glaucoma.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Details
- Title
- Transorbital Alternating Current Stimulation in a Double-Masked Randomized Clinical Trial: Visual Functional Effect and Quality of Life
- Creators
- Maria de los Angeles Ramos Cadena - NYU Langone HealthAshley Sohn - NYU Langone HealthHeather Livengood - West Virginia UniversityTing-Fang Lee - NYU Langone HealthBatsheva Rubin - Wills Eye HospitalJiyuan Hu - NYU Langone HealthBernhard A. Sabel - Otto-von-Guericke-Universität MagdeburgRachel Matayev - NYU Langone HealthJoseph Panarelli - NYU Langone HealthGadi Wollstein - Wills Eye HospitalJoel S. Schuman - Drexel University
- Publication Details
- Ophthalmology science (Online), v 5(1), 100614
- Publisher
- Elsevier
- Grant note
- NIH R01-EY013178 / Research to Prevent Blindness (https://doi.org/10.13039/100001818)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering and Science
- Web of Science ID
- WOS:001355571800001
- Scopus ID
- 2-s2.0-85208230228
- Other Identifier
- 991022197303904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Ophthalmology