Journal article
Transparent MXene Microelectrode Arrays for Multimodal Mapping of Neural Dynamics
Advanced healthcare materials, pe2402576
27 Sep 2024
PMID: 39328088
Abstract
Abstract Transparent microelectrode arrays have proven useful in neural sensing, offering a clear interface for monitoring brain activity without compromising high spatial and temporal resolution. The current landscape of transparent electrode technology faces challenges in developing durable, highly transparent electrodes while maintaining low interface impedance and prioritizing scalable processing and fabrication methods. To address these limitations, we introduce artifact‐resistant transparent MXene microelectrode arrays optimized for high spatiotemporal resolution recording of neural activity. With 60% transmittance at 550 nm, these arrays enable simultaneous imaging and electrophysiology for multimodal neural mapping. Electrochemical characterization shows low impedance of 563 ± 99 kΩ at 1 kHz and a charge storage capacity of 58 mC cm⁻² without chemical doping. In vivo experiments in rodent models demonstrate the transparent arrays' functionality and performance. In a rodent model of chemically‐induced epileptiform activity, we tracked ictal wavefronts via calcium imaging while simultaneously recording seizure onset. In the rat barrel cortex, we recorded multi‐unit activity across cortical depths, showing the feasibility of recording high‐frequency electrophysiological activity. The transparency and optical absorption properties of Ti₃C₂Tx MXene microelectrodes enable high‐quality recordings and simultaneous light‐based stimulation and imaging without contamination from light‐induced artifacts.
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Details
- Title
- Transparent MXene Microelectrode Arrays for Multimodal Mapping of Neural Dynamics
- Creators
- Sneha Shankar - University of PennsylvaniaYuzhang Chen - Translational TherapeuticsSpencer Averbeck - University of PennsylvaniaQuincy Hendricks - University of PennsylvaniaBrendan Murphy - Translational TherapeuticsBenjamin Ferleger - University of PennsylvaniaNicolette Driscoll - University of PennsylvaniaMikhail Shekhirev - Drexel UniversityHajime Takano - Children's Hospital of PhiladelphiaAndrew Richardson - Translational TherapeuticsYury Gogotsi - Drexel UniversityFlavia Vitale - University of Pennsylvania
- Publication Details
- Advanced healthcare materials, pe2402576
- Publisher
- WILEY; HOBOKEN
- Number of pages
- 11
- Grant note
- National Institutes of Health: R01NS121219, R01NS123054 National Institutes of Health (NIH): CAREER 2339748 National Science Foundation: NNCI-2025608
This work was supported by the National Institutes of Health (NIH) Grants No. R01NS121219 (F.V. and Y.G.) and R01NS123054 (F.V.), and the National Science Foundation Grant No. CAREER 2339748 (F.V.)Part of the work was conducted at the Penn Singh Center for Nanotechnology, which is supported by the NSF National Nanotechnology Coordinated Infrastructure Program under grant NNCI-2025608. The authors also would like to acknowledge the use of instruments in the Core Characterization Facility (CCF) of Drexel University.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering; A.J. Drexel Nanomaterials Institute
- Web of Science ID
- WOS:001320150500001
- Scopus ID
- 2-s2.0-85204878631
- Other Identifier
- 991021906610404721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology