Journal article
Transplacental interferon-mediated effect in AKR mice
Virology (New York, N.Y.), v 106(1), pp 148-151
15 Oct 1980
PMID: 6158164
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study was designed to determine whether or not exogenous interferon could produce a modification of virus production in the progeny of mice treated with interferon during gestation. Pregnant AKR mice were treated with exogenous mouse interferon and their progeny examined for the presence of endogenous, ecotropic murine leukemia viruses by the XC assay. Interferon treatment inhibited virus production in most of the progeny for at least 1 week after birth as compared to control mice. The results of this study clearly demonstrates that: (i) treatment of pregnant mice with exogenous interferon mediates a biological effect frequently associated with interferon in their progeny and (ii) the spontaneous production of infectious, ecotropic murine leukemia viruses by AKR mice can be inhibited by treatment during gestation.
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Details
- Title
- Transplacental interferon-mediated effect in AKR mice
- Creators
- Donna Marie Murasko - Drexel UniversityKenneth J. Blank - University of Pennsylvania
- Publication Details
- Virology (New York, N.Y.), v 106(1), pp 148-151
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1980KK73000016
- Scopus ID
- 2-s2.0-0018959785
- Other Identifier
- 991020950770404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology