Journal article
Transplantation of fetal spinal cord tissue into acute and chronic hemisection and contusion lesions of the adult rat spinal cord
Progress in brain research, v 78(C), 21
01 Jan 1988
PMID: 3247421
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This chapter discusses and examines: (1) the pattern of axonal connectivity established with fetal homotopic (that is, spinal cord) grafts into the acutely injured spinal cord, (2) the influence of an existing histopathology on survival of these transplants and their integration with the host spinal cord in chronic lesions, and (3) the feasibility of transplantation into chronic, contusion lesions. It is feasible to transplant embryonic central nervous system (CNS) tissue into various lesions of the adult spinal cord, including those, which may ultimately shed light on the potential clinical application of intraspinal transplantation. These studies also establish a useful neuroanatomical framework for physiological and behavioral tests of the functional impact of these grafts in acute and chronic hemisected and contused spinal cords. While, evidence exists for some axonal connectivity between host and graft, it is still uncertain that an optimal setting has been established under any of these lesion conditions, as indicated in part by the variable glial responses seen in individual transplant recipients. However, intraspinal transplantation has begun to stimulate new avenues of investigation, which will undoubtedly facilitate a more in-depth understanding of the complex biology of the injured spinal cord.
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Details
- Title
- Transplantation of fetal spinal cord tissue into acute and chronic hemisection and contusion lesions of the adult rat spinal cord
- Creators
- P J Reier - University of FloridaJ D Houle - University of FloridaL Jakeman - University of FloridaD Winialski - University of FloridaA Tessler - Drexel University, Medical College of Pennsylvania (1970-1993)
- Publication Details
- Progress in brain research, v 78(C), 21
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1988T512600021
- Scopus ID
- 2-s2.0-0024239903
- Other Identifier
- 991019183925804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences