Journal article
Traveling Theta Waves in the Human Hippocampus
The Journal of neuroscience, v 35(36), pp 12477-12487
09 Sep 2015
PMID: 26354915
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The hippocampal theta oscillation is strongly correlated with behaviors such asmemoryand spatial navigation, but we do not understand its specific functional role. One hint of theta's function came from the discovery in rodents that theta oscillations are traveling waves that allow parts of the hippocampus to simultaneously exhibit separate oscillatory phases. Because hippocampal theta oscillations in humans have different properties compared with rodents, we examined these signals directly using multielectrode recordings from neurosurgical patients. Our findings confirm that human hippocampal theta oscillations are traveling waves, but also show that these oscillations appear at a broader range of frequencies compared with rodents. Human traveling waves showed a distinctive pattern of spatial propagation such that there is a consistent phase spread across the hippocampus regardless of the oscillations' frequency. This suggests that traveling theta oscillations are important functionally in humans because they coordinate phase coding throughout the hippocampus in a consistent manner.
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Details
- Title
- Traveling Theta Waves in the Human Hippocampus
- Creators
- Honghui Zhang - Drexel UniversityJoshua Jacobs - Columbia UniversityHua Zhang - Electrical and Computer Engineering
- Publication Details
- The Journal of neuroscience, v 35(36), pp 12477-12487
- Publisher
- Soc Neuroscience
- Number of pages
- 11
- Grant note
- R01MH061975 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Defense Advanced Research Projects Agency; United States Department of Defense; Defense Advanced Research Projects Agency (DARPA) Brain and Behavior Research Foundation MH061975 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:000363659300015
- Scopus ID
- 2-s2.0-84941254475
- Other Identifier
- 991019173420904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences