Journal article
Treatment of Bilateral Refractive Amblyopia in Children Three to Less Than 10 Years of Age
American journal of ophthalmology, v 144(4), pp 487-496
01 Oct 2007
PMID: 17707330
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose
To determine the amount and time course of binocular visual acuity improvement during treatment of bilateral refractive amblyopia in children three to less than 10 years of age.
Design
Prospective, multicenter, noncomparative intervention.
Methods
One hundred and thirteen children (mean age, 5.1 years) with previously untreated bilateral refractive amblyopia were enrolled at 27 community- and university-based sites and were provided with optimal spectacle correction. Bilateral refractive amblyopia was defined as 20/40 to 20/400 best-corrected binocular visual acuity in the presence of 4.00 diopters (D) or more of hypermetropia by spherical equivalent, 2.00 D or more of astigmatism, or both in each eye. Best-corrected binocular and monocular visual acuities were measured at baseline and at five, 13, 26, and 52 weeks. The primary study outcome was binocular acuity at one year.
Results
Mean binocular visual acuity improved from 0.50 logarithm of the minimum angle of resolution (logMAR) units (20/63) at baseline to 0.11 logMAR units (20/25) at one year (mean improvement, 3.9 lines; 95% confidence interval [CI], 3.5 to 4.2). Mean improvement at one year for the 84 children with baseline binocular acuity of 20/40 to 20/80 was 3.4 lines (95% CI, 3.2 to 3.7) and for the 16 children with baseline binocular acuity of 20/100 to 20/320 was 6.3 lines (95% CI, 5.1 to 7.5). The cumulative probability of binocular visual acuity of 20/25 or better was 21% at five weeks, 46% at 13 weeks, 59% at 26 weeks, and 74% at 52 weeks.
Conclusions
Treatment of bilateral refractive amblyopia with spectacle correction improves binocular visual acuity in children three to less than 10 years of age, with most improving to 20/25 or better within one year.
Metrics
Details
- Title
- Treatment of Bilateral Refractive Amblyopia in Children Three to Less Than 10 Years of Age
- Creators
- The Pediatric Eye Disease Investigator Group (Collaboration)David K Wallace - Duke UniversityDanielle L Chandler - Jaeb Center for Health ResearchDeborah A Klimek - Jaeb Center for Health ResearchIncryd Lorenzana - Jaeb Center for Health ResearchGraham E Quinn - University of PennsylvaniaMichael X Repka - Jaeb Center for Health ResearchDonny W Suh - Wolfe Eye ClinicSusanna Tamkins - University of MiamiRoy W Beck - Jaeb Center for Health ResearchRobert W Arnold - Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, United StatesDarron A Bacal - Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, United StatesEileen E Birch - Retina Foundation of the SouthwestJoost Felius - New England College of OptometryMarcela Frazier - Jaeb Center for Health ResearchJonathan M Holmes - Mayo ClinicDarren Hoover - Ophthalmology Associates (United States)Mitchell M Scheiman - Drexel University, Pennsylvania College of Optometry at Salus University (2008-2025)
- Publication Details
- American journal of ophthalmology, v 144(4), pp 487-496
- Publisher
- Elsevier
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000249937400001
- Scopus ID
- 2-s2.0-34548767761
- Other Identifier
- 991021900815504721
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- Web of Science research areas
- Ophthalmology