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Treatment of Bilateral Refractive Amblyopia in Children Three to Less Than 10 Years of Age
Journal article   Open access   Peer reviewed

Treatment of Bilateral Refractive Amblyopia in Children Three to Less Than 10 Years of Age

The Pediatric Eye Disease Investigator Group, David K Wallace, Danielle L Chandler, Deborah A Klimek, Incryd Lorenzana, Graham E Quinn, Michael X Repka, Donny W Suh, Susanna Tamkins, Roy W Beck, …
American journal of ophthalmology, v 144(4), pp 487-496
01 Oct 2007
DOI: https://doi.org/10.1016/j.ajo.2007.05.040
PMID: 17707330
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc2128700View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Biological and medical sciences Medical sciences Miscellaneous Ophthalmology Vision Disorders
Purpose To determine the amount and time course of binocular visual acuity improvement during treatment of bilateral refractive amblyopia in children three to less than 10 years of age. Design Prospective, multicenter, noncomparative intervention. Methods One hundred and thirteen children (mean age, 5.1 years) with previously untreated bilateral refractive amblyopia were enrolled at 27 community- and university-based sites and were provided with optimal spectacle correction. Bilateral refractive amblyopia was defined as 20/40 to 20/400 best-corrected binocular visual acuity in the presence of 4.00 diopters (D) or more of hypermetropia by spherical equivalent, 2.00 D or more of astigmatism, or both in each eye. Best-corrected binocular and monocular visual acuities were measured at baseline and at five, 13, 26, and 52 weeks. The primary study outcome was binocular acuity at one year. Results Mean binocular visual acuity improved from 0.50 logarithm of the minimum angle of resolution (logMAR) units (20/63) at baseline to 0.11 logMAR units (20/25) at one year (mean improvement, 3.9 lines; 95% confidence interval [CI], 3.5 to 4.2). Mean improvement at one year for the 84 children with baseline binocular acuity of 20/40 to 20/80 was 3.4 lines (95% CI, 3.2 to 3.7) and for the 16 children with baseline binocular acuity of 20/100 to 20/320 was 6.3 lines (95% CI, 5.1 to 7.5). The cumulative probability of binocular visual acuity of 20/25 or better was 21% at five weeks, 46% at 13 weeks, 59% at 26 weeks, and 74% at 52 weeks. Conclusions Treatment of bilateral refractive amblyopia with spectacle correction improves binocular visual acuity in children three to less than 10 years of age, with most improving to 20/25 or better within one year.

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81 citations in Web of Science
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Web of Science research areas
Ophthalmology
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