Journal article
Treatment of Postoperative Nausea and Vomiting With Ondansetron: A Randomized, Double-Blind Comparison With Placebo
Anesthesia and analgesia, v 73(3), pp 246-249
Sep 1991
PMID: 1831015
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Postoperative nausea and vomiting are common after recovery from general anesthesia. The antiemetic effect and safety of ondansetron, a selective serotonin type 3 (5-HT3) receptor antagonist, was determined in 36 patients suffering from nausea or vomiting during recovery from intravenous anesthesia by giving either a single intravenous dose of ondansetron (8 mg, n = 18) or placebo (n = 18) over 2–5 min in a randomized, double-blind manner. A “rescue” antiemetic was provided in case of continued vomiting or at the patientʼs request. Antiemetic efficacy was defined as no request for rescue antiemetic and/or no vomiting episode during the next 4 h. There was no significant difference in the demographic data between the groups. Administration of ondansetron or placebo had no significant effect on vital signs. Ondansetron was an effective antiemetic in 78% (14/18) and placebo was effective in 28% (5/18) of the patients. Laboratory studies 24 h later showed no signs of hematologic, hepatic, or renal alterations. Ondansetron at a dose of 8 mg administered intravenously over 2–5 min appears to be a safe and effective antiemetic for the treatment of nausea and/or vomiting after intravenous anesthesia.
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Details
- Title
- Treatment of Postoperative Nausea and Vomiting With Ondansetron: A Randomized, Double-Blind Comparison With Placebo
- Creators
- Ghassem Larijani - Departments of Anesthesiology, Obstetrics and Gynecology, and Pharmacology, Medical College of Pennsylvania, Philadelphia, PennsylvaniaIrwin GratzMary AfsharShahab Minassian
- Publication Details
- Anesthesia and analgesia, v 73(3), pp 246-249
- Publisher
- International Anesthesia Research Society
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program
- Web of Science ID
- WOS:A1991GC34600002
- Scopus ID
- 2-s2.0-0025775789
- Other Identifier
- 991019184026604721
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- Web of Science research areas
- Anesthesiology