Journal article
Treatment of advanced ovarian cancer with sequential combination chemotherapy
Cancer, v 60(9), pp 2150-2155
01 Nov 1987
PMID: 2830953
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Fifty previously untreated patients with advanced or recurrent ovarian cancer (FIGO Stages III and IV) were treated with alternating combination chemotherapy. This consisted of high‐dose doxorubicin (70 mg/m2) and cisplatin (100 mg/m2) alternated with CHF (cyclophosphamide, hexamethylmelamine, and 5‐fluorouracil). Toxicity (myelosuppression, nephropathy, and neuropathy) was infrequent and mild. Clinical response rates were high (94% responses, 62% complete clinical response), but the majority of patients had residual intraabdominal disease at second‐look surgery (75%). Thirteen patients (26%) are alive after 4 years of observation (minimum follow‐up). Survival was adversely influenced in patients who were older than 70, had Stage IV disease, residual tumor bulk greater than 2 cm, and who failed to achieve complete clinical remission. The median duration of survival (28 months) and percentage of long‐term survivors appear similar to that in other platinum‐based chemotherapy studies. Although the role of alternating combination chemotherapy in epithelial ovarian cancer remains undefined, it is likely that an alternate approach will be necessary to markedly improve survival rates for patients with this disease.
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Details
- Title
- Treatment of advanced ovarian cancer with sequential combination chemotherapy
- Creators
- Thomas W. Griffin - St Vincent HospitalRichard A. Hunter - St Vincent HospitalAndrew I. Cederbaum - St Vincent HospitalWon K. Tak - St Vincent HospitalAllen D. Ward - St Vincent HospitalJoel H. Schwartz - St Vincent HospitalThomas F. Halpin - St Vincent HospitalGary M. Strauss - St Vincent HospitalRowland N. Meyer - St Vincent HospitalMarcia K. Liepman - St Vincent HospitalHarry L. Greene - St Vincent HospitalMary E. Costanza - St Vincent Hospital
- Publication Details
- Cancer, v 60(9), pp 2150-2155
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:A1987K484400004
- Scopus ID
- 2-s2.0-0023200185
- Other Identifier
- 991019184024804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology