Journal article
Treatment of children with chronic hepatitis C with recombinant interferon‐α: A pilot study
Hepatology (Baltimore, Md.), v 16(4), pp 882-885
Oct 1992
PMID: 1328009
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Twelve children with chronic non‐A, non‐B hepatitis were entered in a pilot trial of recombinant interferon‐α. Although all the children had hepatitis C virus RNA in serum, only five had antibodies against this virus. Children received 3 MU/m2 body surface area interferon‐α 3 times/wk for 6 mo; they were followed for 24 mo, including the therapy period. One child was dropped from the study, so the results are from the 11 children who completed the study. At the end of the therapy period, 36% of the children had normal ALT levels; this percentage increased to 90% at mo 15 of follow‐up. Thereafter, relapse occurred in five children; thus ALT normalization was observed in 5 of 11 children at the 24th month. Moreover, two different ALT patterns were found: HCV antibody—negative children had significant peaks of ALT levels with respect to the basal samples (p < 0.05) until the third month of the therapy; these levels later decreased. In contrast, HCV antibody—positive children had slight fluctuations of ALT until normal levels were reached. At the end of treatment, three children had HCV RNA; one demonstrated a rebound in ALT levels. Finally, histological activity had decreased significantly in the second liver biopsy specimen in all children. In summary, interferon treatment in children with chronic hepatitis C may be helpful, although these results should be confirmed in controlled trials. (HEPATOLOGY 1992;16:882–885.)
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Details
- Title
- Treatment of children with chronic hepatitis C with recombinant interferon‐α: A pilot study
- Creators
- Mercedes Ruiz-Moreno - Hospital Universitario Fundación Jiménez DíazMaria José Rua - Hospital Universitario Fundación Jiménez DíazInmaculada Castillo - Hospital Universitario Fundación Jiménez DíazMaria Dolores García-Novo - Hospital Infantil Universitario Niño JesúsMaravillas Santos - Hospital Universitario Fundación Jiménez DíazSonia Navas-Martin - Drexel University, Microbiology and ImmunologyVicente Carreño - Fundación para el Estudio de las Hepatitis Virales
- Publication Details
- Hepatology (Baltimore, Md.), v 16(4), pp 882-885
- Publisher
- W.B. Saunders
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1992JR88300004
- Scopus ID
- 2-s2.0-0026670121
- Other Identifier
- 991022047817704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology