Journal article
Treatment of porcine aortic smooth muscle cells with phorbol esters prevents nodulation in vitro
Cell biology international reports, v 16(3), pp 221-233
1992
PMID: 1581968
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Abstract
Vascular smooth muscle cells exhibit a unique pattern of growth in culture. They have the capacity for multilayer growth and form large macroscopic nodules. We find that nodulation is inhibited in the presence of phorbol esters and that there is a concomitant decrease in the production of a 38 kd secreted protein associated with nodulation in porcine smooth muscle. Examination of the organization of actin filaments within the cells using a rhodamine phalloidin stain indicates that there is a rearrangement of actin filaments in response to phorbol esters. This rearrangement increases the number of attachment sites to the culture surface and may contribute to the inhibition of nodulation in smooth muscle cells by phorbol esters.
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Details
- Title
- Treatment of porcine aortic smooth muscle cells with phorbol esters prevents nodulation in vitro
- Creators
- Christian Sell - Albany Medical Center HospitalPaul Held - University of VermontKilambi Janakidevi - Albany Medical Center Hospital
- Publication Details
- Cell biology international reports, v 16(3), pp 221-233
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:A1992HL00800005
- Scopus ID
- 2-s2.0-0026533068
- Other Identifier
- 991020111310304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology