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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Treatment of severe amblyopia with weekend atropine: Results from 2 randomized clinical trials
Journal of AAPOS, v 13(3), pp 258-263
01 Jun 2009
PMID: 19541265
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
PURPOSE To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age.
METHODS We enrolled children into 2 prospective, randomized multicenter clinical trials of amblyopia therapy. Herein we report the results for severe amblyopia, 20112 5 to 20/400. In Trial 1, 60 children 3 to 6 years of age (mean, 4.4 years) were randomized to weekend atropine plus a piano lens or weekend atropine plus full spectacle correction for the sound eye. In Trial 2, 40 children 7 to 12 years of age (mean, 9.3 years) were randomized to weekend atropine or 2 hours of daily patching. The visual acuity outcome was assessed at IS weeks in Trial 1 and 17 weeks in Trial 2.
RESULTS In Trial 1, visual acuity improved by an average of 4.5 lines in the atropine plus correction group (95% CI, 3.2-5.8 lines) and 5.1 lines in the atropine plus piano lens group (95% CI, 3.7-6.4 lines). In Trial 2, visual acuity improved by an average of 1.5 lines in the atropine group (95% CI, 0.5-2.5 lines) and 1.8 lines in the patching group (95% CI, 1.1-2.6 lines).
CONCLUSIONS Weekend atropine can improve visual acuity in children 3 to 12 years of age with severe amblyopia. Improvement may be greater in younger children. (J AAPOS 2009;13:258-263)
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Details
- Title
- Treatment of severe amblyopia with weekend atropine: Results from 2 randomized clinical trials
- Creators
- Michael X. Repka - Johns Hopkins MedicineRaymond T. Kraker - Jaeb Center for Health ResearchRoy W. Beck - Jaeb Center for Health ResearchEileen Birch - Retina Foundation of the SouthwestSusan A. Cotter - Marshall B. Ketchum UniversityJonathan M. Holmes - Mayo ClinicRichard W. Hertle - Children's Hospital of PittsburghDarren L. Hoover - Ophthalmology AssociatesDeborah L. Klimek - Eye Care AssociatesWendy Marsh-Tootle - University of AlabamaMitchell M. Scheiman - Salus UniversityDonny W. Suh - Wolfe Eye ClinicDavid R. Weakley - Children's Medical CenterPediat Eye Dis Investigator Grp
- Publication Details
- Journal of AAPOS, v 13(3), pp 258-263
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- U10 EY011751-10; U10 EY011751-09; EY011751; U10 EY011751-08; U10 EY011751 / NEI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) U10EY011751 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000267343700009
- Scopus ID
- 2-s2.0-67449105581
- Other Identifier
- 991021900190104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology
- Pediatrics