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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Treatment practices for aspirin-exacerbated respiratory disease: analysis of a national insurance claims database
International forum of allergy & rhinology, v 10(2), pp 190-193
Feb 2020
PMID: 31693796
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aspirin-exacerbated respiratory disease (AERD) is the triad of asthma, nasal polyposis, and sensitivity to cyclooxygenase-1 inhibitors. Treatment options include medical management, surgical intervention, and aspirin desensitization (AsaD).
AERD patients were identified using the MarketScan Database from 2009 to 2015. Patients were included using International Classification of Diseases, 9th edition (ICD-9) codes for asthma, nasal polyposis, and drug allergy. Treatments were determined by Current Procedural Terminology (CPT) codes for drug desensitization and endonasal procedures. Geographic trends and timing of interventions between those exposed and not exposed to desensitization were explored.
A total of 5628 patients met inclusion criteria for AERD, with mean age 46 years, 60% female; 395 (7%) underwent AsaD and 2171 (39%) underwent sinus surgery. Among patients who were desensitized, 229 (58%) underwent surgery, of whom 201 (88%) had surgery prior to AsaD (median [quartile 1, quartile 3]; 61 days [30, 208] prior to desensitization). For patients undergoing surgery following AsaD (n = 46), surgery was performed a median of 302 (163, 758) days after AsaD. Nineteen patients had multiple surgeries post-AsaD with median time between surgeries being 734 days (312, 1484); 261 patients were not desensitized to aspirin but did undergo multiple surgeries, with the median of the median time between surgeries being 287 days (15, 617), which is shorter than for patients post-AsaD (p < 0.001).
A very small percentage of AERD patients undergo AsaD. Patients who had AsaD underwent surgery approximately 2 months prior to AsaD. Patients who underwent AsaD experienced an increased time between surgeries compared to patients who did not undergo AsaD.
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Details
- Title
- Treatment practices for aspirin-exacerbated respiratory disease: analysis of a national insurance claims database
- Creators
- Lauren T Roland - University of California, San FranciscoCeleste Nagy - Emory UniversityHeqiong Wang - Emory UniversityRenee Moore - Emory UniversityKatherine N Cahill - Vanderbilt University Medical CenterTanya M Laidlaw - Brigham and Women's HospitalSarah K Wise - Emory UniversityJohn M DelGaudio - Emory UniversityMerin Kuruvilla - Emory UniversityJoshua M Levy - Emory University
- Publication Details
- International forum of allergy & rhinology, v 10(2), pp 190-193
- Publisher
- Wiley
- Grant note
- K23 AI118804 / NIAID NIH HHS KL2 TR002381 / NCATS NIH HHS UL1 TR002378 / NCATS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000494584700001
- Scopus ID
- 2-s2.0-85074838995
- Other Identifier
- 991021448045204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology