We would like to thank Drs Scott Chamberlain, Francois Michonneau and Josef Uyeda (rOpenSci) and Prof. Martin Morgan (Bioconductor) for providing thorough code review, and the anonymous reviewers for comments on the article. This work was supported by research grants from National Key Plan for Scientific Research and Development of China (2016YFD0500302; 2017YFE0190800), Shenzhen Peacock Plan (KQTD201203), National Institutes of Health (HHSN272201400006C), NSFC-Guangdong Joint Foundation of China (U1601225), Open Project of Guangdong Provincial Key Laboratory of Proteomics (20191001A), and Startup fund from Southern Medical University (G618289088).