Journal article
Trends in utilization of advanced therapies in patients with inflammatory bowel diseases in the USA, 2021-2025
Journal of Crohn's and colitis, v 19(10), 186
08 Nov 2025
PMID: 41134654
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Aims: Seven new advanced therapies, belonging to three new classes, have been approved for the treatment of inflammatory bowel diseases (IBD) since 2021. We examined trends in utilization of advanced therapies in the USA since 2021. Methods: Using de-identified electronic health record data from 71 US health systems, we examined quarterly trends in utilization of different advanced therapies in patients with ulcerative colitis and Crohn's disease between 2021 and 2025, using interrupted time-series analysis utilizing Prais-Winsten regression. Results: In 11 093 patients with ulcerative colitis treated with advanced therapies, we observed an increase in use of upadacitinib (12.1% in Q2/2025; P < .001, compared with first quarter of prescription), interleukin-23p19 (IL23p19) antagonists (5.5%; P = .03), and ustekinumab (9.5%; P = .04), decline in use of tumor necrosis factor (TNF) antagonists (34.5%; P = .003), and stable use of vedolizumab (33.6%; P = .17) and sphingosine-1 phosphate receptor modulators (1.6%; P = .28). In 15 951 patients with Crohn's disease treated with advanced therapies, we observed an increase in use of IL23p19 antagonists (15.0% in Q1/2025; P = .003) and upadacitinib (5.9%; P < .001) and decline in use of TNF antagonists (50.2%; P = .001) and ustekinumab (13.5%; P < .001). Conclusions: Contemporary trends in advanced therapy utilization in patients with IBD suggest an increased utilization of upadacitinib and anti-interleukins, accompanied by a decline in use of TNF antagonists in the USA.
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Details
- Title
- Trends in utilization of advanced therapies in patients with inflammatory bowel diseases in the USA, 2021-2025
- Creators
- Siddharth Singh - Mayo Clinic in ArizonaAakash Desai - Drexel University, General Internal MedicineShane Goodwin - London Health Sciences CentreVipul Jairath - Western UniversityGursimran Kochhar - Drexel University, General Internal Medicine
- Publication Details
- Journal of Crohn's and colitis, v 19(10), 186
- Publisher
- Oxford Univ Press
- Number of pages
- 5
- Grant note
- R01DK13593701A1 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001615857700001
- Scopus ID
- 2-s2.0-105021670099
- Other Identifier
- 991022130651104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology