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Trevo 2000: Results of a Large Real-World Registry for Stent Retriever for Acute Ischemic Stroke
Journal article   Open access

Trevo 2000: Results of a Large Real-World Registry for Stent Retriever for Acute Ischemic Stroke

Mandy J Binning, Bruno Bartolini, Blaise Baxter, Ronald Budzik, Joey English, Rishi Gupta, Hirad Hedayat, Antonin Krajina, David Liebeskind, Raul G Nogueira, …
Journal of the American Heart Association, v 7(24), pp e010867-e010867
18 Dec 2018
DOI: https://doi.org/10.1161/JAHA.118.010867
PMID: 30561262
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1161/jaha.118.010867View
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open
url
https://doi.org/10.1161/JAHA.118.010867View
Published, Version of Record (VoR) Open

Abstract

Aged Aged, 80 and over Brain Ischemia - diagnosis Brain Ischemia - mortality Brain Ischemia - physiopathology Brain Ischemia - therapy Databases, Factual Disability Evaluation Endovascular Procedures - adverse effects Endovascular Procedures - instrumentation Endovascular Procedures - mortality Female Humans Male Middle Aged Prospective Studies Prosthesis Design Recovery of Function Registries Risk Factors Stents Stroke - diagnosis Stroke - mortality Stroke - physiopathology Stroke - therapy Thrombectomy - adverse effects Thrombectomy - instrumentation Thrombectomy - mortality Time Factors Treatment Outcome
Background Recent randomized controlled trials show benefit of thrombectomy for large vessel occlusion in stroke. Real-world data aid in assessing reproducibility of outcomes outside of clinical trials. The Trevo Retriever Registry is a multicenter, international, prospective study designed to assess outcomes in a large cohort of patients. Methods and Results The Trevo Registry is a prospective database of patients with large vessel occlusion treated with the Trevo device as the first device. The primary end point is revascularization based on modified Thrombolysis in Cerebral Infarction score and secondary end points include 90-day modified Rankin Scale, 90-day mortality, neurological deterioration at 24 hours, and device/procedure related adverse events. Year 2008 patients were enrolled at 76 centers in 12 countries. Median admission National Institutes of Health Stroke Scale was 16 (interquartile range, 11-20). Occlusion sites were internal carotid artery (17.8%), middle cerebral artery (73.5%), posterior circulation (7.1%), and distal vascular locations (1.6%). A modified Thrombolysis in Cerebral Infarction 2b or 3 was achieved in 92.8% (95% CI, 91.6, 93.9) of procedures, with 55.3% (95% CI, 53.1, 57.5) of patients achieving modified Rankin Scale ≤2 at 3 months. Patients meeting revised 2015 American Heart Association criteria for thrombectomy had a 59.7% (95% CI , 56.0; 63.4) modified Rankin Scale 0 to 2 at 3 months, whereas 51.4% treated outside of American Heart Association criteria had modified Rankin Scale 0 to 2. 51.4% (95% CI , 49.6, 55.4). Symptomatic intracranial hemorrhage rate was 1.7% (95% CI , 1.2, 2.4). Conclusions The Trevo Retriever Registry represents real-world data with stent retriever. The registry demonstrates similar reperfusion rates and outcomes in the community compared with rigorous centrally adjudicated clinical trials. Future subgroup analysis of this cohort will assist in identifying areas of future research. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique identifier: NCT 02040259.

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55 citations in Web of Science
50 citations in Scopus

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Collaboration types
Domestic collaboration
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Web of Science research areas
Cardiac & Cardiovascular Systems
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