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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Trials and Tribulations with VH Replacement
Frontiers in immunology, v 5, pp 10-10
30 Jan 2014
PMCID: PMC3906580
PMID: 24523721
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
VH replacement (VHR) is a type of antibody gene rearrangement in which an upstream heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In this Hypothesis and Theory article, we begin by reviewing the mechanism of VHR, its developmental timing and its potential biological consequences. Then we explore the hypothesis that specific sequence motifs called footprints reflect VHR versus other processes. We provide a compilation of footprint sequences from different regions of the antibody heavy chain, and include data from the literature and from a high throughput sequencing experiment to evaluate the significance of footprint sequences. We conclude by discussing the difficulties of attributing footprints to VHR.
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Details
- Title
- Trials and Tribulations with VH Replacement
- Creators
- Wenzhao Meng - University of PennsylvaniaSahana Jayaraman - University of PennsylvaniaBochao Zhang - , , , , , , , , , , , ,Gregory W. Schwartz - Drexel UniversityRobert D. Daber - University of PennsylvaniaUri Hershberg - Drexel UniversityAlfred L. Garfall - University of PennsylvaniaChristopher S. Carlson - Fred Hutchinson Cancer Research CenterEline T. Luning Prak - , , , , , , , , , , , ,
- Publication Details
- Frontiers in immunology, v 5, pp 10-10
- Publisher
- Frontiers Media S.A
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000354034200002
- Scopus ID
- 2-s2.0-84895521131
- Other Identifier
- 991019176638604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology