Journal article
Tryptophan Hydroxylase 1 Gene Polymorphisms Alter Prefrontal Cortex Activation During Response Inhibition
Neuropsychology, v 30(1), pp 18-27
01 Jan 2016
PMID: 26710093
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: The tryptophan hydroxylase 1 gene (TPH1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin. Variations in the gene encoding this enzyme may underlie difficulties in impulse control; however, the proximate relationship between risk alleles for polymorphisms in the TPH1 gene and the neural correlates of response inhibition remain poorly understood. The present study examined the relationship of 2 single nucleotide polymorphisms in the TPH1 gene (rs1799913 and rs4537731) to prefrontal cortex (PFC) activation on a response inhibition task. Method: Evoked hemodynamic oxygenation in the PFC was measured in 30 unrelated healthy adult women using 16-channel continuous-wave functional near-infrared spectroscopy while they completed a manual go/no-go task. Results: TPH1 alleles showed no association with demographic characteristics, general intelligence, impulsive personality traits, or accuracy and response latency indices on the go/no-go task. Participants carrying the risk alleles, however, showed less activity primarily in bilateral inferior frontal gyri and medial PFC under conditions of response inhibition. Conclusions: Polymorphisms in the TPH1 gene may be represented by diminished activity in lateral areas of the PFC underlying response inhibition. Reduced activity in medial PFC might represent altered self-monitoring of performances on the response inhibition task.
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Details
- Title
- Tryptophan Hydroxylase 1 Gene Polymorphisms Alter Prefrontal Cortex Activation During Response Inhibition
- Creators
- Anthony C. Ruocco - University of TorontoAchala H. Rodrigo - University of TorontoDean Carcone - University of TorontoShelley McMain - Centre for Addiction and Mental HealthGrace Jacobs - Centre for Addiction and Mental HealthJames L. Kennedy - Centre for Addiction and Mental HealthHasan Ayaz - School of Biomedical Engineering, Science, and Health Systems (1997-)
- Publication Details
- Neuropsychology, v 30(1), pp 18-27
- Publisher
- Amer Psychological Assoc
- Number of pages
- 10
- Grant note
- University of Toronto Scarborough; University of Toronto 123413; MSH-130177 / Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel Solutions Institute; College of Arts and Sciences; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000367326600003
- Scopus ID
- 2-s2.0-84952802325
- Other Identifier
- 991019276220004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Psychology
- Psychology, Clinical