Journal article
Tumor Necrosis Factor (TNF) and Lymphotoxin-alpha (LTA) Polymorphisms and Risk of Non-Hodgkin Lymphoma in the InterLymph Consortium
American journal of epidemiology, v 171(3), pp 267-276
01 Feb 2010
PMID: 20047977
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF -308G > A (rs1800629), lymphotoxin-alpha (LTA) 252A > G (rs909253), IL10 -3575T > A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for "new" participant TNF -308A carriers (NHL: per-allele odds ratio (ORallelic) = 1.10, P-trend = 0.001; diffuse large B-cell lymphoma (DLBCL): ORallelic = 1.23, P-trend = 0.004). In the combined population, odds ratios were increased for TNF -308A carriers (NHL: ORallelic = 1.13, P-trend = 0.0001; DLBCL: ORallelic = 1.25, P-trend = 3.7 x 10(-6); marginal zone lymphoma: ORallelic = 1.35, P-trend = 0.004) and LTA 252G carriers (DLBCL: ORallelic = 1.12, P-trend = 0.006; mycosis fungoides: ORallelic = 1.44, P-trend = 0.015). The LTA 252A > G/TNF -308G > A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P = 2.9 x 10(-8)). Results suggested associations between IL10 -3575T > A and DLBCL (P-trend = 0.02) and IL10 -1082A > G and mantle cell lymphoma (P-trend = 0.04). These findings strengthen previous results for DLBCL and the LTA 252A > G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology.
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Details
- Title
- Tumor Necrosis Factor (TNF) and Lymphotoxin-alpha (LTA) Polymorphisms and Risk of Non-Hodgkin Lymphoma in the InterLymph Consortium
- Creators
- Christine F. Skibola - University of California, BerkeleyPaige M. Bracci - University of California, San FranciscoAlexandra Nieters - German Cancer Research CenterAngela Brooks-Wilson - Simon Fraser UniversitySilvia de Sanjose - Institut Català d'OncologiaAnn Maree Hughes - The University of SydneyJames R. Cerhan - College Station Medical CenterDanica R. Skibola - University of California, BerkeleyMark Purdue - National Institutes of HealthEleanor Kane - University of YorkQing Lan - National Institutes of HealthLenka Foretova - Masaryk Memorial Cancer InstituteMaryjean Schenk - Wayne State UniversityJohn J. Spinelli - University of British ColumbiaSusan L. Slager - Mayo ClinicAnneclaire J. De Roos - National Institutes of HealthMartyn T. Smith - University of California, BerkeleyEve Roman - University of YorkWendy Cozen - University of Southern CaliforniaPaolo Boffetta - Centre international de recherche sur le cancerAnne Kricker - The University of SydneyTongzhang Zheng - Yale UniversityTracy Lightfoot - University of YorkPierluigi Cocco - University of CagliariYolanda Benavente - Institut Català d'OncologiaYawei Zhang - Yale UniversityPatricia Hartge - National Institutes of HealthMartha S. Linet - National Institutes of HealthNikolaus Becker - German Cancer Research CenterPaul Brennan - Centre international de recherche sur le cancerLuoping Zhang - Mayo Clinic College of Medicine and ScienceBruce Armstrong - The University of SydneyAlex Smith - University of YorkRenee Shiao - University of California, BerkeleyAnne J. Novak - Mayo ClinicMarc Maynadie - Université de BourgogneStephen J. Chanock - National Institutes of HealthAnthony Staines - Dublin City UniversityTheodore R. Holford - Yale UniversityElizabeth A. Holly - University of California, San FranciscoNathaniel Rothman - National Institutes of HealthSophia S. Wang - City of Hope
- Publication Details
- American journal of epidemiology, v 171(3), pp 267-276
- Publisher
- Oxford Univ Press
- Number of pages
- 10
- Grant note
- DJCLS-R04/08 / Jose Carreras Leukemia Foundation NO1-CO-12400 CA62 006 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Compagnia di San Paolo-Programma Oncologia; Compagnia di San Paolo P42ES004705 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) QLK4-CT-2000-00422 / European Commission; European Commission Joint Research Centre Leukaemia Research Fund Health and Medical Research Council of Australia, the Cancer Council New South Wales, and the University of Sydney Medical Foundation Program; Cancer Council New South Wales R01CA122663 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) PI040091; PI041467 / Fondo Investigaciones Sanitarias; Instituto de Salud Carlos III 03/09 / Network for Research in Epidemiology and Public Health StSch4261; StSch4420 / Federal Office for Radiation Protection Cancer Research, Ireland Michael Smith Foundation for Health Research National Cancer Institute of Canada; Canadian Cancer Society (CCS) CA104862; CA45614; CA89745; CA87014; NO1-CO-12400; CA92153 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000273866000001
- Scopus ID
- 2-s2.0-75149123908
- Other Identifier
- 991020100056404721
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- Collaboration types
- Domestic collaboration
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- Web of Science research areas
- Public, Environmental & Occupational Health