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Tumor bed-to-skin distance using accelerated partial-breast irradiation with the strut-adjusted volume implant device
Journal article   Peer reviewed

Tumor bed-to-skin distance using accelerated partial-breast irradiation with the strut-adjusted volume implant device

Brandon Fisher, Larry Daugherty, Talha Shaikh, Jay Reiff, Dan Perlingiero, Fiori Alite, Luther Brady and Lydia Komarnicky
Brachytherapy, v 11(5), pp 387-391
01 Sep 2012
DOI: https://doi.org/10.1016/j.brachy.2011.09.009
PMID: 22104353
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Life Sciences & Biomedicine Oncology Radiology, Nuclear Medicine & Medical Imaging Science & Technology
PURPOSE: Because of the risk of skin toxicity with single dwell position, single-lumen brachytherapy devices are sometimes contraindicated for tumor cavities 5-7 mm from the skin surface. We discuss the use of multicatheter device to treat patients with tumor bed-to-skin distances <7 mm. METHODS AND MATERIALS: We treated 117 patients with accelerated partial-breast irradiation brachytherapy: 77 single-lumen and 40 multicatheter devices. A subset of 12 patients treated with SAVI (R) had bed-to-skin spacing <7 mm. All patients had Tis-2N0 ductal carcinoma with negative margins. A total dose of 34.0 Gy in 10 fractions was delivered twice daily. Planning target volume was created using computed tomography based three-dimensional planning with a 1.0-cm expansion of the lumpectomy cavity. Skin dose was measured dosimetrically, with skin constraints <125% of the prescription. Toxicities were graded, and patients were assessed at various intervals. RESULTS: Of the patients treated with the multicatheter device, 0% (0/12) had their device pulled. At 2 weeks after treatment, fewer than 50% of the patients had skin toxicities of Grades 1-2, all of which resolved by 6 months. The cosmetic outcome was good to excellent at followup. CONCLUSIONS: Multicatheter devices permit well-tolerated accelerated partial-breast irradiation in patients with tumor cavities near the skin surface for which the single-lumen device may not be appropriate. Published by Elsevier Inc. on behalf of American Brachytherapy Society.

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Web of Science research areas
Oncology
Radiology, Nuclear Medicine & Medical Imaging
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