Files and links (1)
SubmittedOpen Access (License Unspecified), Open
Journal article
Tumor pathogenesis of human neurotropic JC virus in the CNS
Journal of neurovirology, v 4(2), pp 175-181
1998
PMID: 9584954
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Broad and Vine, MS 406, Philadephia, Pennsylvania 19102, USA
In the last several years, studies have reported the detection of sequences similar to the polyomavirus, Simian Virus 40 (SV40) in human tumors including choroid plexus papillomas and ependymomas. Taken together with well-established evidence that SV40, as well as the human polyomaviruses JC virus (JCV) and BK virus (BKV), are oncogenic in several animal models, new interest has resurfaced regarding a possible role for these viruses in human tumors. In particular, a strong case can be made for re-evaluating the oncogenic potential of JCV in a neurotropic polyomavirus which is the causative agent of the fatal human demyelinating disease, Progressive Multifocal Leukoencepha-lopathy (PML). In this review, we discuss the transforming capability of JCV in vitro, JCV's ability to induce neural origin tumors in non-human primates as well as in rodents, and several case reports which suggest a possible role for JCV in tumor pathogenesis in the central nervous system.
Metrics
Details
- Title
- Tumor pathogenesis of human neurotropic JC virus in the CNS
- Creators
- Gary L Gallia - Allegheny University of the Health SciencesJennifer Gordon - Allegheny University of the Health SciencesKamel Khalili - Allegheny University of the Health SciencesToya S Gordon - Obstetrics and Gynecology
- Publication Details
- Journal of neurovirology, v 4(2), pp 175-181
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Obstetrics and Gynecology
- Web of Science ID
- WOS:000073010200004
- Scopus ID
- 2-s2.0-0031980448
- Other Identifier
- 991019167714504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Virology