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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: A potential mechanism for intercellular HIV trafficking
Cellular immunology, v 254(2), pp 142-148
01 Jan 2009
PMID: 18835599
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cell to cell communication is essential for the organization/coordination of multicellular systems and cellular development. Cellular communication is mediated by soluble factors, including growth factors, neurotransmitters, cytokines/chemokines, gap junctions, and the recently described tunneling nanotubes (TNT). TNT are long cytoplasmatic bridges that enable long range directed communication between cells. The proposed function for TNT is the cell-to-cell transfer of large cellular structures such as vesicles and organelles. We demonstrate that HIV-infection of human macrophages results in an increased number of TNT, and show HIV particles within these structures. We propose that HIV "highjacks" TNT communication to spread HIV through an intercellular route between communicated cells, contributing to the pathogenesis of AIDS. (c) 2008 Elsevier Inc. All rights reserved.
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Details
- Title
- Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: A potential mechanism for intercellular HIV trafficking
- Creators
- E. A. Eugenin - Albert Einstein College of MedicineP. J. Gaskill - Yeshiva UniversityJ. W. Berman - Yeshiva University
- Publication Details
- Cellular immunology, v 254(2), pp 142-148
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- F32DA024965 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission P30AI051519 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32NS007098 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01MH075679 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:000262330400010
- Scopus ID
- 2-s2.0-57249097160
- Other Identifier
- 991020111294004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Immunology