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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Two-Dimensional Ti 3 C 2 MXene for High-Resolution Neural Interfaces
ACS nano, v 12(10), p10419
23 Oct 2018
PMID: 30207690
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
High-resolution neural interfaces are essential tools for studying and modulating neural circuits underlying brain function and disease. Because electrodes are miniaturized to achieve higher spatial resolution and channel count, maintaining low impedance and high signal quality becomes a significant challenge. Nanostructured materials can address this challenge because they combine high electrical conductivity with mechanical flexibility and can interact with biological systems on a molecular scale. Unfortunately, fabricating high-resolution neural interfaces from nanostructured materials is typically expensive and time-consuming and does not scale, which precludes translation beyond the benchtop. Two-dimensional (2D) Ti
C
MXene possesses a combination of remarkably high volumetric capacitance, electrical conductivity, surface functionality, and processability in aqueous dispersions distinct among carbon-based nanomaterials. Here, we present a high-throughput microfabrication process for constructing Ti
C
neuroelectronic devices and demonstrate their superior impedance and in vivo neural recording performance in comparison with standard metal microelectrodes. Specifically, when compared to gold microelectrodes of the same size, Ti
C
electrodes exhibit a 4-fold reduction in interface impedance. Furthermore, intraoperative in vivo recordings from the brains of anesthetized rats at multiple spatial and temporal scales demonstrate that Ti
C
electrodes exhibit lower baseline noise, higher signal-to-noise ratio, and reduced susceptibility to 60 Hz interference than gold electrodes. Finally, in neuronal biocompatibility studies, neurons cultured on Ti
C
are as viable as those in control cultures, and they can adhere, grow axonal processes, and form functional networks. Overall, our results indicate that Ti
C
MXene microelectrodes have the potential to become a powerful platform technology for high-resolution biological interfaces.
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Details
- Title
- Two-Dimensional Ti 3 C 2 MXene for High-Resolution Neural Interfaces
- Creators
- Nicolette Driscoll - Center for Neurotrauma, Neurodegeneration, and Restoration , Corporal Michael J. Crescenz Veterans Affairs Medical Center , Philadelphia , Pennsylvania 19104 , United StatesAndrew G RichardsonKathleen MaleskiBabak AnasoriOladayo Adewole - Center for Neurotrauma, Neurodegeneration, and Restoration , Corporal Michael J. Crescenz Veterans Affairs Medical Center , Philadelphia , Pennsylvania 19104 , United StatesPavel LelyukhLilia Escobedo - School of Chemical and Biomolecular Engineering , Cornell University , Ithaca , New York 14853 , United StatesD Kacy Cullen - Center for Neurotrauma, Neurodegeneration, and Restoration , Corporal Michael J. Crescenz Veterans Affairs Medical Center , Philadelphia , Pennsylvania 19104 , United StatesTimothy H LucasYury GogotsiFlavia Vitale - Center for Neurotrauma, Neurodegeneration, and Restoration , Corporal Michael J. Crescenz Veterans Affairs Medical Center , Philadelphia , Pennsylvania 19104 , United States
- Publication Details
- ACS nano, v 12(10), p10419
- Publisher
- American Chemical Society; Washington, DC
- Grant note
- U01 NS094340 / NINDS NIH HHS I01 BX003748 / BLRD VA T32 NS091006 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000448751800080
- Scopus ID
- 2-s2.0-85053602746
- Other Identifier
- 991014969889904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology