Journal article
Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion
Nano letters, v 17(1), pp 384-391
01 Jan 2017
PMID: 28026960
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ceramic biomaterials have been investigated for several decades, but their potential biomedical applications in cancer therapy have been paid much less attentions, mainly due to their lack of related material functionality for combating the cancer. In this work, we report, for the first time, that MAX ceramic biomaterials exhibit the unique functionality for the photothermal ablation of cancer upon being exfoliated into ultrathin nanosheets within atomic thickness (MXene). As a paradigm, biocompatible Ti3C2 nanosheets (MXenes) were successfully synthesized based on a two-step exfoliation strategy of MAX phase Ti3AlC2 by the combined HF etching and TPAOH intercalation. Especially, the high photothermal-conversion efficiency and in vitro/in vivo photothermal ablation of tumor of Ti3C2 nanosheets (MXenes) were revealed and demonstrated, not only in the intravenous administration of soybean phospholipid modified Ti3C2 nanosheets but also in the localized intratumoral implantation of a phase-changeable PLGA/Ti3C2 organic-inorganic hybrid. This work promises the great potential of Ti3C2 nanosheets (MXenes) as a novel ceramic photothermal agent used for cancer therapy and may arouse much interest in exploring MXene-based ceramic biomaterials to benefit the biomedical applications.
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Details
- Title
- Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion
- Creators
- Han Lin - Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R ChinaXingang Wang - Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R ChinaLuodan Yu - University of Chinese Academy of SciencesYu Chen - Shanghai Institute of CeramicsJianlin Shi - Shanghai Institute of Ceramics
- Publication Details
- Nano letters, v 17(1), pp 384-391
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 8
- Grant note
- 13ZR1463500 / Natural Science Foundation of Shanghai 2016YFA0203700 / National Key Research and Development Program of China 51302293; 51132009 / National Nature Science Foundation of China; National Natural Science Foundation of China (NSFC) 2013169 / Youth Innovation Promotion Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000392036600055
- Scopus ID
- 2-s2.0-85016274617
- Other Identifier
- 991019187051704721
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Highly Cited Paper
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter