Two large (up to 16.9 and 25.3 mm long), many-ribbed, shallow water species of Epitonium. are newly described: E. phymanthi from southeast Florida, the Bahamas, and the West Indies, and E. worsfoldi from the Bahamas and the West Indies. Where possible, rib counts were made on each shell whorl to allow for ontogenetic changes. Epitonium phymanthi lives with and feeds on the sea anemone Phymanthus crucifer in Florida (where E. lamellosum and another epitoniid Opalia crenata also live with this anemone). Likewise, E. worsfoldi lives with and feeds on a sand-dwelling anemone that is either Actinoporus elegans or Homostichanthus duerdeni in the Bahamas. There it is more commonly parasitic on another anemone, Stichodactyla helianthus. Aquarium observations on E. phymanthi with E. lamellosum revealed some major biological differences between these co-occurring species, e.g. fully everted proboscis lengths and speed of movement. Epitonium phymanthi was found with E. worsfoldi at only one locality, as shells in the Virgin Islands.