Journal article
Two-allergen model reveals complex relationship between IgE crosslinking and degranulation
Chemistry & biology, v 21(11), pp 1445-1451
20 Nov 2014
PMID: 25308278
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Allergy is an immune response to complex mixtures of multiple allergens, yet current models use a single synthetic allergen. Multiple allergens were modeled using two well-defined tetravalent allergens, each specific for a distinct IgE, thus enabling a systematic approach to evaluate the effect of each allergen and percentage of allergen-specific IgE on mast cell degranulation. We found the overall degranulation response caused by two allergens is additive for low allergen concentrations or low percent specific IgE, does not change for moderate allergen concentrations with moderate to high percent specific IgE, and is reduced for high allergen concentrations with moderate to high percent specific IgE. These results provide further evidence that supraoptimal IgE crosslinking decreases the degranulation response and establishes the two-allergen model as a relevant experimental system to elucidate mast cell degranulation mechanisms.
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Details
- Title
- Two-allergen model reveals complex relationship between IgE crosslinking and degranulation
- Creators
- Michael W Handlogten - University of Notre DamePeter E Deak - University of Notre DameBasar Bilgicer - University of Notre Dame
- Publication Details
- Chemistry & biology, v 21(11), pp 1445-1451
- Publisher
- Elsevier
- Grant note
- R56 AI108884 / NIAID NIH HHS R01 AI108884 / NIAID NIH HHS R03 AI085485 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000345506900005
- Scopus ID
- 2-s2.0-84911900491
- Other Identifier
- 991019520427304721
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- Web of Science research areas
- Biochemistry & Molecular Biology