Journal article
Type 2 diabetes mellitus is a strong predictor of LDL cholesterol target achievement in patients with peripheral artery disease
JOURNAL OF DIABETES AND ITS COMPLICATIONS, v 34(11), 107692
Nov 2020
PMID: 32878717
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and aims: Patients with peripheral artery disease (PAD) arc at a very high risk of cardiovascular events and strongly benefit from lowering LDL cholesterol (LDL-C); updated European Society of Cardiology guidelines recommend an LDL-C target of at least <55 mg/dl for these patients. Whether the presence of type 2 diabetes (T2DM) affects LDL-C target achievement in PAD patients is unknown and is addressed in the present study. Methods: We investigated an unselected consecutive series of 319 patients with sonographically proven PAD, of whom 136 (42.6%) had T2DM. Results: The LDL-C target of <55 mg/dl was met by 8.1% of T2DM patients and by 2.2% of non-diabetic patients (p = 0.014); LDL-C was <70 mg/dl in 22.8% of patients with T2DM and in 9.8% of non-diabetic patients (p = 0.002). Logistic regression analysis showed that the presence of T2DM was an independent and strong predictor of LDL-C target achievement after multivariate adjustment including age, gender, potency adjusted statin use, BMI, smoking, hypertension and other lipid-modifying therapy for the <55 mg/dl target (OR 3.58 [1.08-11.90]; p = 0.038) as well as for the <70 mg/dl target (OR 2.78 [1.40-5.35]; p = 0.003). Conclusion: We conclude that T2DM is a strong and independent predictor of LDL-C target achievement among PAD patients; however, also among PAD patients with T2DM only a minority meets the current target of <55 mg/di and most patients do not even have an LDL-C < 70 mg/dl. (C) 2020 Elsevier Inc. All rights reserved.
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Details
- Title
- Type 2 diabetes mellitus is a strong predictor of LDL cholesterol target achievement in patients with peripheral artery disease
- Publication Details
- JOURNAL OF DIABETES AND ITS COMPLICATIONS, v 34(11), 107692
- Publisher
- ELSEVIER SCIENCE INC; NEW YORK
- Grant note
- We thank the Jubilaumsfonds of the Austrian National Bank (Vienna, Austria), Dr. Karl Josef Hier and the Peter Goop Stiftung (Vaduz, Liechtenstein), the Fachhochschule Dornbirn (Dornbirn, Austria), and the Institute for Clinical Chemistry at the Academic Teaching Hospital Feldkirch (Feldkirch, Austria) for providing us with generous research grants.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000573474800007
- Scopus ID
- 2-s2.0-85089958380
- Other Identifier
- 991021860766104721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism