Journal article
Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons
Cell reports (Cambridge), v 15(2), pp 386-397
12 Apr 2016
PMID: 27050508
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Proneural proteins of the class I/II basic-helix-loop-helix (bHLH) family are highly conserved transcription factors. Class I bHLH proteins are expressed in a broad number of tissues during development, whereas class II bHLH protein expression is more tissue restricted. Our understanding of the function of class I/II bHLH transcription factors in both invertebrate and vertebrate neurobiology is largely focused on their function as regulators of neurogenesis. Here, we show that the class I bHLH proteins Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation. Our data indicate that Daughterless performs this function in part by restricting the expression of the cell adhesion molecule Neurexin. This suggests a role for these proteins outside of their established roles in neurogenesis.
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•bHLH proteins Daughterless and Tcf4 are present in postmitotic neurons•bHLH proteins Daughterless and Tcf4 restrict branching in postmitotic neurons•Daughterless and Tcf4 repress Neurexin expression in postmitotic neurons•Daughterless homodimers restrict branching in postmitotic neurons
Class I bHLH proneural proteins are highly conserved transcription factors generally recognized as critical for neurogenesis. D’Rozario et al. show that the Drosophila and mouse class I bHLH proteins Daughterless and Tcf4 are present in postmitotic, differentiated neurons and function to restrict neurite branch and synapse number.
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Details
- Title
- Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons
- Creators
- Mitchell D’Rozario - Department of Biology, Drexel University, Philadelphia, PA 19104, USATing Zhang - Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USAEdward A Waddell - Department of Biology, Drexel University, Philadelphia, PA 19104, USAYonggang Zhang - Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USACem Sahin - Department of Electrical and Computer Engineering, Drexel University, Philadelphia, PA 19104, USAMichal Sharoni - Department of Biology, Drexel University, Philadelphia, PA 19104, USATina Hu - Department of Biology, Drexel University, Philadelphia, PA 19104, USAMohammad Nayal - Department of Biology, Drexel University, Philadelphia, PA 19104, USAKaveesh Kutty - Department of Biology, Drexel University, Philadelphia, PA 19104, USAFaith Liebl - Department of Biological Sciences, Southern Illinois University Edwardsville, Edwardsville, IL 62026, USAWenhui Hu - Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USADaniel R Marenda - Department of Biology, Drexel University, Philadelphia, PA 19104, USA
- Publication Details
- Cell reports (Cambridge), v 15(2), pp 386-397
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000374236900016
- Scopus ID
- 2-s2.0-84962110241
- Other Identifier
- 991014878020104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology