Journal article
Ultra-Fast Low Concentration Detection of Candida Pathogens Utilizing High Resolution Micropore Chips
Sensors (Basel, Switzerland), v 9(3), pp 1590-1598
Mar 2009
PMID: 22573974
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although
Candida
species are the fourth most common cause of nosocomial blood stream infections in the United States, early diagnostic tools for invasive candidemia are lacking. Due to an increasing rate of candidemia, a new screening system is needed to detect the
Candida
species in a timely manner. Here we describe a novel method of detection using a solid-state micro-scale pore similar to the operational principles of a Coulter counter. With a steady electrolyte current flowing through the pore, measurements are taken of changes in the current corresponding to the shape of individual yeasts as they translocate or travel through the pore. The direct ultra-fast low concentration electrical addressing of
C. albicans
has established criteria for distinguishing individual yeast based on their structural properties, which may reduce the currently used methods’ complexity for both identification and quantification capabilities in mixed blood samples.
Metrics
Details
- Title
- Ultra-Fast Low Concentration Detection of Candida Pathogens Utilizing High Resolution Micropore Chips
- Creators
- Rafael Mulero - Department of Mechanical Engineering & Mechanics, Drexel University, Philadelphia, PA 19104, U.S.A. E-MailDong Heun Lee - Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, U.S.A. E-MailsMichele A Kutzler - Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, U.S.A. E-MailsJeffrey M Jacobson - Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, U.S.A. E-MailsMin Jun Kim - Department of Mechanical Engineering & Mechanics, Drexel University, Philadelphia, PA 19104, U.S.A. E-Mail
- Publication Details
- Sensors (Basel, Switzerland), v 9(3), pp 1590-1598
- Publisher
- Molecular Diversity Preservation International (MDPI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine); Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000264572700021
- Scopus ID
- 2-s2.0-63849193929
- Other Identifier
- 991014878582904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Analytical
- Engineering, Electrical & Electronic
- Instruments & Instrumentation