Journal article
Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery
Biomaterials, v 161, pp 292-305
01 Apr 2018
PMID: 29427925
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Beyond mesoporous silica nanoparticles (MSNs), mesoporous organosilica nanoparticles (MONs) have been becoming an even more attractive alternative to the traditional organic or inorganic nanomaterials in biomedical applications, especially for drug delivery, due to its high surface area, stable physicochemical properties, low toxicity, high biocompatibility, and particularly the devisable features decided by the incorporated organic fragments. However, it is still challenging to fabricate uniform ultrasmall MONs with tunable composition, morphology and fine biodegradability. Herein, we report, on the large-scale fabrication of monodispersed and molecularly organic-inorganic hybrid MON5 with framework incorporated physiologically active thioether bonds, controllable nanostructure, composition and morphology, which provides the material foundation for exploring the versatile biomedical applications of organosilica nanosystems. The hybrid MONs of less than 50 nm in particle size exhibit the unique reduction-responsive biodegradation behavior, and the biodegradation rate is significantly higher than that of traditional mesoporous silica nanoparticles with pure inorganic Si-O-Si framework. The reductive microenvironment-triggered biodegradation of MONs induces the concurrent reduction responsive anticancer drug releasing from MONs, enabling tumor-specific drug delivery. Importantly, these biocompatible and biodegradable MONs exhibit significantly improved drug-delivery efficiency and enhanced tumor-suppressing effect for combating cancer. Based on the facile and large-scale fabrication of MONs with controllable key structure/composition/morphology parameters, unique tumor microenvironment-responsive biodegradation behavior and high performance for drug delivery, the MONs therefore show more promising potentials for clinical translation as compared to traditional MSNs. (C) 2018 Elsevier Ltd. All rights reserved.
Metrics
Details
- Title
- Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery
- Creators
- Luodan Yu - Shanghai Institute of CeramicsYu Chen - Shanghai Institute of CeramicsHan Lin - Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R ChinaWenxian Du - Shanghai Institute of CeramicsHangrong Chen - Shanghai Institute of CeramicsJianlin Shi - Shanghai Institute of Ceramics
- Publication Details
- Biomaterials, v 161, pp 292-305
- Publisher
- Elsevier
- Number of pages
- 14
- Grant note
- 51722211; 51672303 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2015QNRC001 / Young Elite Scientist Sponsorship Program by CAST 2016YFA0203700; 2017YFB0702602 / National Key Research and Development Program of China 2013169 / Youth Innovation Promotion Association of the Chinese Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000427100300025
- Scopus ID
- 2-s2.0-85041455822
- Other Identifier
- 991019186959104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials