Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance
Journal of immunology research, v 2021, pp 6664453-33
10 Feb 2021
PMID: 33628851
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background. The immune mechanisms underlying low-intensity ultrasound- (LIUS-) mediated suppression of inflammation and tumorigenesis remain poorly determined. Methods. We used microarray datasets from the NCBI GEO DataSet repository and conducted comprehensive data-mining analyses, where we examined the gene expression of 1376 innate immune regulators (innatome genes (IGs) in cells treated with LIUS. Results. We made the following findings: (1) LIUS upregulates proinflammatory IGs and downregulates metastasis genes in cancer cells, and LIUS upregulates adaptive immunity pathways but inhibits danger-sensing and inflammation pathways and promote tolerogenic differentiation in bone marrow (BM) cells. (2) LIUS upregulates IGs encoded for proteins localized in the cytoplasm, extracellular space, and others, but downregulates IG proteins localized in nuclear and plasma membranes, and LIUS downregulates phosphatases. (3) LIUS-modulated IGs act partially via several important pathways of reactive oxygen species (ROS), reverse signaling of immune checkpoint receptors B7-H4 and BTNL2, inflammatory cytokines, and static or oscillatory shear stress and heat generation, among which ROS is a dominant mechanism. (4) LIUS upregulates trained immunity enzymes in lymphoma cells and downregulates trained immunity enzymes and presumably establishes trained tolerance in BM cells. (5) LIUS modulates chromatin long-range interactions to differentially regulate IGs expression in cancer cells and noncancer cells. Conclusions. Our analysis suggests novel molecular mechanisms that are utilized by LIUS to induce tumor suppression and inflammation inhibition. Our findings may lead to development of new treatment protocols for cancers and chronic inflammation.
Metrics
Details
- Title
- Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance
- Creators
- Qian Yang - Temple UniversityRuijing Zhang - Temple UniversityPeng Tang - China Rehabilitation Research CenterYu Sun - Temple UniversityCandice Johnson - Temple UniversityJason Saredy - Temple UniversitySusu Wu - Temple UniversityJiwei Wang - Temple UniversityYifan Lu - Temple UniversityFatma Saaoud - Temple UniversityYing Shao - Temple UniversityCharles Drummer - Temple UniversityKeman Xu - Temple UniversityDaohai Yu - Temple UniversityRongshan Li - Second Hospital of Shanxi Medical UniversityShuping Ge - St. Christopher's Hospital for ChildrenXiaohua Jiang - Temple UniversityHong Wang - Temple UniversityXiaofeng Yang - Temple University
- Publication Details
- Journal of immunology research, v 2021, pp 6664453-33
- Publisher
- Hindawi Publishing Group
- Number of pages
- 33
- Grant note
- R01 DK104116; R01 DK113775 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01 HL131460; R01 HL130233 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000621851900002
- Scopus ID
- 2-s2.0-85101613668
- Other Identifier
- 991019167664904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology