Journal article
Ultrasound triggered drug delivery with liposomal nested microbubbles
Ultrasonics, v 63
Dec 2015
PMID: 26152887
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
When ultrasound contrast agent microbubbles are nested within a liposome, damage to the liposome membrane caused by both stable and inertial cavitation of the microbubble allows for release of the aqueous core of the liposome. Triggered release was not accomplished unless microbubbles were present within the liposome. Leakage was tested using fluorescence assays developed specifically for this drug delivery vehicle and qualitative measurements using an optical microscope. These studies were done using a 1 MHz focused ultrasound transducer while varying parameters including peak negative ultrasound pressure, average liposome diameter, and microbubble concentration. Two regimes exist for membrane disruption caused by cavitating microbubbles. A faster release rate, as well as permanent membrane damage are seen for samples exposed to high pressure (2.1-3.7 MPa). A slower release rate and dilation/temporary poration are characteristic of stable cavitation for low pressure studies (0.54-1.7 MPa).
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Details
- Title
- Ultrasound triggered drug delivery with liposomal nested microbubbles
- Creators
- N Wallace - Drexel UniversityS P Wrenn - Drexel University
- Publication Details
- Ultrasonics, v 63
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000359603000005
- Scopus ID
- 2-s2.0-84947342708
- Other Identifier
- 991019167554204721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging