Journal article
Ultrastructural and Morphological Analyses of the In Vitro and In Vivo Hemostatic Effects of Ankaferd Blood Stopper
Clinical and applied thrombosis/hemostasis, v 16(4), pp 446-453
01 Aug 2010
PMID: 19833624
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ultrastructural and morphological analyses of a novel hemostatic agent, Ankaferd Blood Stopper (ABS), in comparison to its in vitro and in vivo hemostatic effects were investigated. High-resolution scanning electron microscopy (SEM) images accompanied with morphological analysis after topical application of ABS revealed a very rapid (<1 second) protein network formation within concurrent vital erythroid aggregation covering the classical coagulation cascade. Histopathological examination revealed similar in vivo ABS-induced hemostatic network at the porcine hepatic tissue injury model. Instantaneous control of bleeding was achieved in human surgery-induced dental tissue injury associated with primary and secondary hemostatic abnormalities. Ankaferd Blood Stopper could hold a great premise for clinical management of surgery bleedings as well as immediate cessation of bleeding on external injuries based on upcoming clinical trials.
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Details
- Title
- Ultrastructural and Morphological Analyses of the In Vitro and In Vivo Hemostatic Effects of Ankaferd Blood Stopper
- Creators
- Berat Z. Haznedaroglu - University of California, RiversideIbrahim C. Haznedaroglu - Hacettepe UniversitySharon L. Walker - University of California, RiversideHasan Bilgili - Ankara UniversityHakan Goker - Hacettepe UniversityAli Kosar - Fatih UniversityAlper Aktas - Hacettepe UniversityOzge Captug - Ankara UniversityMevlut Kurt - Türkiye Yüksek İhtisas HastanesiOktay Oezdemir - Yorum Consultancy, Dept Sci Res, Istanbul, TurkeySerafettin Kirazli - Ankaferd Inc, Dept Res & Dev, Istanbul, TurkeyHuseyin C. Firat - Ankaferd Inc, Dept Res & Dev, Istanbul, Turkey
- Publication Details
- Clinical and applied thrombosis/hemostasis, v 16(4), pp 446-453
- Publisher
- Sage
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Engineering
- Web of Science ID
- WOS:000280131300011
- Scopus ID
- 2-s2.0-77954917620
- Other Identifier
- 991021230001604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Hematology
- Peripheral Vascular Disease