Journal article
Ultrastructural tubular basement membrane lesions in adult polycystic kidney disease
Annals of clinical and laboratory science, v 19(5), pp 352-359
Sep 1989
PMID: 2802515
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The pathogenesis of adult polycystic kidney disease (PCKD) remains an enigma. In an attempt to find a defect that might explain the cyst formation, an ultrastructural study was performed on seven fresh bilateral nephrectomies of seven patients suffering from adult PCKD. Marked electron microscopic changes of the tubular basement membranes were detected, including thickening, splitting, fraying, and multilayering of the basement membranes. By contrast, glomerular basement membranes lacked these alterations. The kidneys from two control groups (five donor kidneys harvested for transplantation; 10 patients who suffered from end stage renal disease) showed none of the lesions detected in the polycystic kidneys. The lesions of the tubular basement membrane, the principal support of tubular wall, may be the primary phenotypic expression and cause of the inherited defect.
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Details
- Title
- Ultrastructural tubular basement membrane lesions in adult polycystic kidney disease
- Creators
- S K Katz - Department of Pathology and Laboratory Medicine, Hahnemann University School of Medicine, Philadelphia, PA 19102A HakkiA S MillerS D Finkelstein
- Publication Details
- Annals of clinical and laboratory science, v 19(5), pp 352-359
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:A1989AM05200006
- Scopus ID
- 2-s2.0-0024319057
- Other Identifier
- 991019184018804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medical Laboratory Technology