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Journal article
Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
Nature reviews. Rheumatology, v 8(1)
01 Jan 2012
PMID: 22025123
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Fibrosis in multiple organs is a prominent pathological finding and distinguishing hallmark of systemic sclerosis (SSc). Findings during the past 5 years have contributed to a more complete understanding of the complex cellular and molecular underpinning of fibrosis in SSc. Fibroblasts, the principal effector cells, are activated in the profibrotic cellular milieu by cytokines and growth factors, developmental pathways, endothelin 1 and thrombin. Innate immune signaling via Toll-like receptors, matrix-generated biomechanical stress signaling via integrins, hypoxia and oxidative stress seem to be implicated in perpetuating the process. Beyond chronic fibroblast activation, fibrosis represents a failure to terminate tissue repair, coupled with an expanded population of mesenchymal cells originating from bone marrow and transdifferentiation of epithelial cells, endothelial cells and pericytes. In addition, studies have identified intrinsic alterations in SSc fibroblasts resulting from epigenetic changes, as well as altered microRNA expression that might underlie the cell-autonomous, persistent activation phenotype of these cells. Precise characterization of the deregulated extracellular and intracellular signaling pathways, mediators and cellular differentiation programs that contribute to fibrosis in SSc will facilitate the development of selective, targeted therapeutic strategies. Effective antifibrotic therapy will ultimately involve novel compounds and repurposing of drugs that are already approved for other indications.
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Details
- Title
- Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
- Creators
- Swati Bhattacharyya - Northwestern UniversityJun Wei - Northwestern UniversityJohn Varga - Northwestern UniversityCarol Artlett - Microbiology and Immunology
- Publication Details
- Nature reviews. Rheumatology, v 8(1)
- Publisher
- Springer Nature
- Number of pages
- 13
- Grant note
- AR 42309 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AR042309 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) Scleroderma Research Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000298382100008
- Scopus ID
- 2-s2.0-84655175061
- Other Identifier
- 991020200753004721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Rheumatology