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Understanding the impact of relapses in the overall course of MS; refinement of the 2 stage natural history model
Journal article   Peer reviewed

Understanding the impact of relapses in the overall course of MS; refinement of the 2 stage natural history model

Thomas F. Scott
Journal of neuroimmunology, v 305, pp 162-166
15 Apr 2017
DOI: https://doi.org/10.1016/j.jneuroim.2017.02.011
PMID: 28284338
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Multiple sclerosis (MS) Natural history Progression Progression of disability Progressive Relapse
Recent studies suggest a need for refinement of the traditional two phase model of relapse onset multiple sclerosis (RMS) to include dynamically changing subgroups within the broad category of secondary progressive MS (SPMS). These studies challenge the traditional notion that relapses play a minor role in comparison to a secondary progressive (perhaps degenerative) process. Patients fulfilling the broad definition for SPMS may take several courses, including variable rates and patterns of overall worsening. New paradigms or models for mapping the trajectory of disability in RMS and SPMS (clinical phenotyping), including periods of remission, may impact our understanding of the underlying pathology, and will be important in assessing treatments. •Relapse with immediate sequella is common in relapse onset multiple sclerosis (RMS).•Severe worsening in RMS often occurs stepwise rather than slowly.•Stepwise worsening at any time is predictive of long term worsening.•These findings represent a refinement of the 2 stage model of RMS.

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9 citations in Web of Science
10 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Web of Science research areas
Immunology
Neurosciences
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