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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Understanding the role of sex on outcomes for the cancer patient undergoing treatment with immune checkpoint inhibitors: a scoping review protocol
BMJ open, v 12(7), pp e059782-e059782
21 Jul 2022
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
IntroductionImmune checkpoint inhibitors (ICIs) have changed the treatment landscape for multiple cancer types. Sex plays an important role in both the development of cancer as well as the functioning of the immune system. Though a difference in response to immune therapy is emerging between men and women it is unclear how this difference affects cancer outcomes and what the potential underlying mechanisms are for those effects. The objective of this study is to describe the influence that sex has on the outcomes experienced by cancer patients on ICI therapy and to identify and analyse any knowledge gaps in the field.Method and analysisThe framework for this methodology was guided by the Joanna Briggs Institute Manual for Evidence Synthesis. The search and review will be conducted from January 2022 to June 2022. Two independent researchers will screen titles and abstracts followed by full-text screening for manuscript inclusion. Full length studies published between 2010 and December 2021 found in PubMed, Cochrane, CINAHL, and Scopus describing the influence of sex differences on cancer outcomes in patients treated with ICIs will be included. After data are extracted it will be summarised for presentation.Ethics and disseminationThe findings of this scoping review will be published in a peer-reviewed journal. The results will be used to inform future studies on the potential differential impacts of ICIs. All data are from published openly accessible sources and therefore no ethical clearance is necessary.
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Details
- Title
- Understanding the role of sex on outcomes for the cancer patient undergoing treatment with immune checkpoint inhibitors: a scoping review protocol
- Creators
- Amy L Shaver - Thomas Jefferson UniversityNikita Nikita - Department of Medical Oncology, Thomas Jefferson University - Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USASwapnil Sharma - Department of Medical Oncology, Thomas Jefferson University - Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USADaniel S Lefler - Department of Medical Oncology, Thomas Jefferson University - Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USAAtrayee Basu-Mallick - Department of Medical Oncology, Thomas Jefferson University - Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USAJennifer M Johnson - Department of Medical Oncology, Thomas Jefferson University - Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USAMeghan L Butryn - Drexel UniversityGrace Lu-Yao - Jefferson College of Population Health, Philadelphia, Pennsylvania, USA
- Publication Details
- BMJ open, v 12(7), pp e059782-e059782
- Publisher
- British Medical Journal Publishing Group
- Grant note
- 5P30CA056036 / Center for Strategic Scientific Initiatives, National Cancer Institute (http://dx.doi.org/10.13039/100008637)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Center for Weight, Eating and Lifestyle Science (WELL) [Historical]
- Web of Science ID
- WOS:000829479100016
- Scopus ID
- 2-s2.0-85134787269
- Other Identifier
- 991019168381904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology