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Unit-Cell Based Design and Modeling in Tissue Engineering Applications
Journal article   Open access   Peer reviewed

Unit-Cell Based Design and Modeling in Tissue Engineering Applications

Connie Gomez, Ali Shokoufandeh and Wei Sun
Computer-aided design and applications, v 4(5), pp 649-659
01 Jan 2007
url
https://doi.org/10.1080/16864360.2007.10738499View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open

Abstract

multi-scale modeling tissue scaffolding Topological connectivity
This work makes a three-fold contribution for a unit-cell based methodology for designing tissue scaffolds. We present a study on unit-cell informatics; we also propose computational methods to characterize unit-cells, and finally we develop criteria for connectivity between unit-cells. We will define a set of unit-cell parameters relevant for the geometrical, structural, mechanical, transport, and biological properties in tissue engineering applications. We will also present computation and engineering based approaches to evaluate unit-cell properties. We will also develop a combinatorial framework to study the unit-cell topological connectivity and scaffold properties. Using this information, we will be able to design an interconnected 3D porous scaffold to meet application requirements.

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