Journal article
Universal DNA methylation age across mammalian tissues
Nature aging, v 3(9), pp 1144-1166
01 Sep 2023
PMID: 37563227
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.
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Details
- Title
- Universal DNA methylation age across mammalian tissues
- Creators
- A T Lu - University of California, Los AngelesZ Fei - University of California, Los AngelesA Haghani - University of California, Los AngelesT R Robeck - SeaWorld EntertainmentJ A Zoller - University of California, Los AngelesC Z Li - University of California, Los AngelesR Lowe - Altos LabsQ Yan - Fleet Science CenterJ Zhang - University of California, Los AngelesH Vu - University of California, Los AngelesJ Ablaeva - University of RochesterV A Acosta-Rodriguez - The University of Texas Southwestern Medical CenterD M Adams - University of Maryland, College ParkJ Almunia - Fundación A LA PARA Aloysius - University of KentuckyR Ardehali - University of California, Los AngelesA Arneson - University of California, Los AngelesC S Baker - Oregon State UniversityG Banks - Nottingham Trent UniversityK Belov - University of SydneyN C Bennett - University of PretoriaP Black - Busch Gardens Tampa, Tampa, FL, USAD T Blumstein - University of California, Los AngelesE K Bors - Oregon State UniversityC E Breeze - Altius Institute for Biomedical SciencesR T Brooke - Epigenetic Clock Development Foundation, Los Angeles, CA, USAJ L Brown - Smithsonian Conservation Biology InstituteG G Carter - The Ohio State UniversityA Caulton - AgResearchJ M Cavin - Dolphin Interconnect SolutionsL Chakrabarti - University of NottinghamI Chatzistamou - University of South CarolinaH Chen - University of Tennessee Health Science CenterK Cheng - University of California, Los AngelesP Chiavellini - Biochemistry Research Institute of La PlataO W Choi - University of California, Los AngelesS M Clarke - AgResearchL N Cooper - Northeast Ohio Medical UniversityM L Cossette - Trent UniversityJ Day - Taronga Conservation Society AustraliaJ DeYoung - University of California, Los AngelesS DiRocco - SeaWorld EntertainmentC Dold - SeaWorld EntertainmentE E Ehmke - Duke UniversityC K Emmons - NOAA National Marine Fisheries Service Northwest Fisheries Science CenterS Emmrich - University of RochesterE Erbay - Altos LabsC Erlacher-Reid - SeaWorld EntertainmentC G Faulkes - Queen Mary University of LondonS H Ferguson - Fisheries and Oceans CanadaC J Finno - University of California, DavisJ E Flower - Sea Research FoundationJ M Gaillard - Université Claude Bernard Lyon 1E Garde - Grønlands NaturinstitutL Gerber - UNSW SydneyV N Gladyshev - Harvard UniversityV Gorbunova - University of RochesterR G Goya - Biochemistry Research Institute of La PlataM J Grant - University of AucklandC B Green - The University of Texas Southwestern Medical CenterE N Hales - University of California, DavisM B Hanson - NOAA National Marine Fisheries Service Northwest Fisheries Science CenterD W Hart - University of PretoriaM Haulena - Vancouver AquariumK Herrick - SeaWorld EntertainmentA N Hogan - National Human Genome Research InstituteC J Hogg - University of SydneyT A Hore - University of OtagoT Huang - University at Buffalo, State University of New YorkJ C Izpisua Belmonte - Altos LabsA J Jasinska - University of California, Los AngelesG Jones - University of BristolE Jourdain - Norwegian Orca Survey, Andenes, NorwayO Kashpur - Tufts Medical CenterH Katcher - Yuvan Research, Mountain View, CA, USAE Katsumata - Sea WorldV Kaza - University of South CarolinaH Kiaris - University of South CarolinaM S Kobor - University of British ColumbiaP Kordowitzki - Institute of Animal Reproduction and Food ResearchW R Koski - LGLM Krützen - University of ZurichS B Kwon - University of California, Los AngelesB Larison - University of California, Los AngelesS G Lee - Brigham and Women's HospitalM Lehmann - Biochemistry Research Institute of La PlataJ F Lemaitre - Laboratoire de Biométrie et Biologie EvolutiveA J Levine - University of California, Los AngelesC Li - University of California, Los AngelesX Li - University of California, Los AngelesA R Lim - University of California, Los AngelesD T S Lin - University of British ColumbiaD M Lindemann - SeaWorld EntertainmentT J Little - University of EdinburghN Macoretta - University of RochesterD Maddox - White Oak Conservation, Yulee, FL, USAC O Matkin - North Gulf Oceanic Society, Homer, AK, USAJ A Mattison - National Institute on AgingM McClure - ABS Global, DeForest, WI, USAJ Mergl - Marineland of Canada, Niagara Falls, Ontario, CanadaJ J Meudt - University of Wisconsin–MadisonG A Montano - SeaWorld EntertainmentK Mozhui - University of Tennessee Health Science CenterJ Munshi-South - Fordham UniversityA Naderi - University of South CarolinaM Nagy - Museum für NaturkundeP Narayan - University of AucklandP W Nathanielsz - Texas Biomedical Research InstituteN B Nguyen - University of California, Los AngelesC Niehrs - Institute of Molecular BiologyJ K O'Brien - Taronga Conservation Society AustraliaP O'Tierney Ginn - Tufts UniversityD T Odom - Cancer Research UKA G Ophir - Cornell UniversityS Osborn - SeaWorld EntertainmentE A Ostrander - National Human Genome Research InstituteK M Parsons - NOAA National Marine Fisheries Service Northwest Fisheries Science CenterK C Paul - University of California, Los AngelesM Pellegrini - University of California, Los AngelesK J Peters - University of ZurichA B Pedersen - University of EdinburghJ L Petersen - University of Nebraska–LincolnD W Pietersen - University of PretoriaG M Pinho - Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USAJ Plassais - Cancer GeneticsJ R Poganik - Brigham and Women's HospitalN A Prado - Adelphi UniversityP Reddy - Salk Institute for Biological StudiesB Rey - Université Claude Bernard Lyon 1B R Ritz - UCLA HealthJ Robbins - Center for Coastal StudiesM Rodriguez - Miami Seaquarium, Miami, FL, USAJ Russell - SeaWorld EntertainmentE Rydkina - University of RochesterL L Sailer - Cornell UniversityA B Salmon - South Texas Veterans Health Care SystemA Sanghavi - Yuvan Research, Mountain View, CA, USAK M Schachtschneider - University of Illinois at ChicagoD Schmitt - Missouri State UniversityT Schmitt - SeaWorld EntertainmentL Schomacher - Institute of Molecular BiologyL B Schook - University of Illinois at ChicagoK E Sears - University of California, Los AngelesA W Seifert - University of KentuckyA Seluanov - University of RochesterA B A Shafer - Trent UniversityD Shanmuganayagam - University of Wisconsin–MadisonA V Shindyapina - Brigham and Women's HospitalM Simmons - Duke UniversityK Singh - Narsee Monjee Institute of Management StudiesI Sinha - University of California, Los AngelesJ Slone - University at Buffalo, State University of New YorkR G Snell - University of AucklandE Soltanmaohammadi - University of South CarolinaM L Spangler - University of Nebraska–LincolnM C Spriggs - Busch Gardens Tampa, Tampa, FL, USAL Staggs - SeaWorld EntertainmentN Stedman - Busch Gardens Tampa, Tampa, FL, USAK J Steinman - SeaWorld San DiegoD T Stewart - Acadia UniversityV J Sugrue - University of OtagoB Szladovits - Royal Veterinary CollegeJ S Takahashi - Howard Hughes Medical InstituteM Takasugi - University of RochesterE C Teeling - University College DublinM J Thompson - University of California, Los AngelesB Van Bonn - Shedd AquariumS C Vernes - University of St AndrewsD Villar - Queen Mary University of LondonH V Vinters - University of California, Los AngelesM C Wallingford - Tufts Medical CenterN Wang - University of California, Los AngelesR K Wayne - University of California, Los AngelesG S Wilkinson - University of Maryland, College ParkC K Williams - University of California, Los AngelesR W Williams - University of Tennessee Health Science CenterX W Yang - University of California, Los AngelesM Yao - University of California, Los AngelesB G Young - Fisheries and Oceans CanadaB Zhang - Brigham and Women's HospitalZ Zhang - Brigham and Women's HospitalP Zhao - Broad CenterY Zhao - University of RochesterW Zhou - Children's Hospital of PhiladelphiaJ Zimmermann - Koblenz University of Applied SciencesJ Ernst - University of California, Los AngelesK Raj - Altos LabsS Horvath - University of California, Los Angeles
- Publication Details
- Nature aging, v 3(9), pp 1144-1166
- Publisher
- Springer Nature
- Grant note
- U01 AG060908 / NIA NIH HHS P30 AG013319 / NIA NIH HHS HHSN268201600003C / NHLBI NIH HHS HHSN268201600001C / NHLBI NIH HHS R01 AG065403 / NIA NIH HHS R21 AG055841 / NIA NIH HHS HHSN268201500001I / NHLBI NIH HHS MR/T021985/1 / Medical Research Council HHSN268201500001C / NHLBI NIH HHS P01 AG051449 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biodiversity, Earth, and Environmental Science (BEES)
- Web of Science ID
- WOS:001053469000001
- Scopus ID
- 2-s2.0-85165881383
- Other Identifier
- 991021904310404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology
- Neurosciences