Journal article
Unmasking of Partial Diabetes Insipidus during Stress but Not Maintenance Dosing of Glucocorticoids in an Infant with Septo-Optic Dysplasia
International journal of pediatric endocrinology, v 2011(1), pp 817954-817954
01 Jan 2011
PMID: 21603211
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
. It is well acknowledged that glucocorticoid (GC) replacement can unmask diabetes insipidus (DI) in subjects with hypopituitarism.
Objective
. To increase the awareness and monitoring for transient and symptomatic DI in children with partial hypopituitarism during periods in which increased GC needs are required.
Methods/Case
. A 2-month-old female infant with septo-optic dysplasia (SOD; on thyroid and maintenance GC replacement therapy at 8 mg/m
2
/day) developed transient DI during 2 separate episodes of stress (one hypothermia, one febrile) when stress dosing of GC (25 mg/m
2
/day) was instituted.
Conclusion
. Children not diagnosed with DI during initial evaluation for hypopituitarism may benefit from rescreening of serum sodium levels during acute periods of stress that demand "stress" GC dosing. This will permit treatment and/or increased vigilance for ensuing permanent DI.
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Details
- Title
- Unmasking of Partial Diabetes Insipidus during Stress but Not Maintenance Dosing of Glucocorticoids in an Infant with Septo-Optic Dysplasia
- Creators
- Mala Puri - University of North Carolina at Chapel HillAnita Azam - University of North Carolina at Chapel HillKarenJ Loechner - Division of Pediatric Endocrine, Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA
- Publication Details
- International journal of pediatric endocrinology, v 2011(1), pp 817954-817954
- Publisher
- BioMed Central
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000215856900004
- Other Identifier
- 991021448164104721
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- Web of Science research areas
- Endocrinology & Metabolism